FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156975935> ?p ?o ?g. }

• W2156975935 endingPage "725" @default.
• W2156975935 startingPage "718" @default.
• W2156975935 abstract "The brain sigma-1 receptors can bind neurosteroids and psychotropic drugs, including neuroleptics and cocaine and are implicated in schizophrenia, depression, and drug dependence. In this study, we found that sigma-1 receptors specifically target lipid storage sites (lipid droplets) on the endoplasmic reticulum by forming a distinct class of lipid microdomains. Both endogenously expressing sigma-1 receptors and transfected C-terminally enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) target unique ring-like structures associated with endoplasmic reticulum reticular networks in NG108-15 cells. The ring-like structures contain neutral lipids and are enlarged by the oleate treatment, indicating that they are endoplasmic reticulum-associated lipid droplets (ER-LDs). sigma-1 receptors colocalize with caveolin-2, a cholesterol-binding protein in lipid rafts on the ER-LDs, but not with adipocyte differentiation-related protein (ADRP), a cytosolic lipid droplet (c-LD)-specific protein. When the double-arginine ER retention signal on the N terminus of sigma-1 receptors is truncated, sigma-1 receptors no longer exist on ER-LDs, but predominantly target c-LDs, which contain ADRP. sigma-1 receptors on ER-LDs form detergent-resistant raft-like lipid microdomains, the buoyancy of which is different from that of plasma membrane lipid rafts. (+)-Pentazocine causes sigma-1 receptors to disappear from the microdomains. N-Terminally EYFP-tagged sigma-1 receptors (EYFP-Sig-1R) failed to target ER-LDs. EYFP-Sig-1R-transfected cells showed an unrestricted distribution of neutral lipids all over the endoplasmic reticulum network, decreases in c-LDs and cholesterol in plasma membranes, and the bulbous aggregation of endoplasmic reticulum. Thus, sigma-1 receptors are unique endoplasmic reticulum proteins that regulate the compartmentalization of lipids on the endoplasmic reticulum and their export from the endoplasmic reticulum to plasma membrane and c-LDs." @default.
• W2156975935 created "2016-06-24" @default.
• W2156975935 creator A5054530429 @default.
• W2156975935 creator A5063051115 @default.
• W2156975935 date "2003-05-02" @default.
• W2156975935 modified "2023-10-08" @default.
• W2156975935 title "σ-1 Receptors (σ₁Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export" @default.
• W2156975935 cites W1564861448 @default.
• W2156975935 cites W1577282977 @default.
• W2156975935 cites W1945140151 @default.
• W2156975935 cites W1963565483 @default.
• W2156975935 cites W1970897378 @default.
• W2156975935 cites W1971392424 @default.
• W2156975935 cites W1979826545 @default.
• W2156975935 cites W1983823375 @default.
• W2156975935 cites W1990711213 @default.
• W2156975935 cites W1992336722 @default.
• W2156975935 cites W1994224293 @default.
• W2156975935 cites W2003532781 @default.
• W2156975935 cites W2003742510 @default.
• W2156975935 cites W2031242571 @default.
• W2156975935 cites W2036777870 @default.
• W2156975935 cites W2038360643 @default.
• W2156975935 cites W2041298355 @default.
• W2156975935 cites W2041389478 @default.
• W2156975935 cites W2043237666 @default.
• W2156975935 cites W2046475919 @default.
• W2156975935 cites W2047764483 @default.
• W2156975935 cites W2054597500 @default.
• W2156975935 cites W2067901635 @default.
• W2156975935 cites W2072291193 @default.
• W2156975935 cites W2073824045 @default.
• W2156975935 cites W2085617663 @default.
• W2156975935 cites W2086475971 @default.
• W2156975935 cites W2094414462 @default.
• W2156975935 cites W2116803744 @default.
• W2156975935 cites W2128963767 @default.
• W2156975935 cites W2130692500 @default.
• W2156975935 cites W2147963733 @default.
• W2156975935 cites W2151459233 @default.
• W2156975935 cites W2408822320 @default.
• W2156975935 cites W2415104265 @default.
• W2156975935 doi "https://doi.org/10.1124/jpet.103.051284" @default.
• W2156975935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12730355" @default.
• W2156975935 hasPublicationYear "2003" @default.
• W2156975935 type Work @default.
• W2156975935 sameAs 2156975935 @default.
• W2156975935 citedByCount "233" @default.
• W2156975935 countsByYear W21569759352012 @default.
• W2156975935 countsByYear W21569759352013 @default.
• W2156975935 countsByYear W21569759352014 @default.
• W2156975935 countsByYear W21569759352015 @default.
• W2156975935 countsByYear W21569759352016 @default.
• W2156975935 countsByYear W21569759352017 @default.
• W2156975935 countsByYear W21569759352018 @default.
• W2156975935 countsByYear W21569759352019 @default.
• W2156975935 countsByYear W21569759352020 @default.
• W2156975935 countsByYear W21569759352021 @default.
• W2156975935 countsByYear W21569759352022 @default.
• W2156975935 countsByYear W21569759352023 @default.
• W2156975935 crossrefType "journal-article" @default.
• W2156975935 hasAuthorship W2156975935A5054530429 @default.
• W2156975935 hasAuthorship W2156975935A5063051115 @default.
• W2156975935 hasConcept C103133801 @default.
• W2156975935 hasConcept C134088382 @default.
• W2156975935 hasConcept C158617107 @default.
• W2156975935 hasConcept C170493617 @default.
• W2156975935 hasConcept C185592680 @default.
• W2156975935 hasConcept C25095133 @default.
• W2156975935 hasConcept C2778938600 @default.
• W2156975935 hasConcept C41625074 @default.
• W2156975935 hasConcept C55493867 @default.
• W2156975935 hasConcept C79266657 @default.
• W2156975935 hasConcept C86803240 @default.
• W2156975935 hasConcept C95444343 @default.
• W2156975935 hasConceptScore W2156975935C103133801 @default.
• W2156975935 hasConceptScore W2156975935C134088382 @default.
• W2156975935 hasConceptScore W2156975935C158617107 @default.
• W2156975935 hasConceptScore W2156975935C170493617 @default.
• W2156975935 hasConceptScore W2156975935C185592680 @default.
• W2156975935 hasConceptScore W2156975935C25095133 @default.
• W2156975935 hasConceptScore W2156975935C2778938600 @default.
• W2156975935 hasConceptScore W2156975935C41625074 @default.
• W2156975935 hasConceptScore W2156975935C55493867 @default.
• W2156975935 hasConceptScore W2156975935C79266657 @default.
• W2156975935 hasConceptScore W2156975935C86803240 @default.
• W2156975935 hasConceptScore W2156975935C95444343 @default.
• W2156975935 hasIssue "2" @default.
• W2156975935 hasLocation W21569759351 @default.
• W2156975935 hasLocation W21569759352 @default.
• W2156975935 hasOpenAccess W2156975935 @default.
• W2156975935 hasPrimaryLocation W21569759351 @default.
• W2156975935 hasRelatedWork W1574104792 @default.
• W2156975935 hasRelatedWork W2067164933 @default.
• W2156975935 hasRelatedWork W2088785967 @default.
• W2156975935 hasRelatedWork W2132865828 @default.
• W2156975935 hasRelatedWork W2283214140 @default.
• W2156975935 hasRelatedWork W2781493717 @default.

• next