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• W2156988210 abstract "Abstract Unlike in most animals, oocytes of marine nemertean worms initiate maturation (=germinal vesicle breakdown, GVBD) following an increase, rather than a decrease, in intraoocytic cAMP. To analyze how serine/threonine (Ser/Thr) kinase cascades involving mitogen‐activated protein kinase (MAPK), maturation‐promoting factor (MPF), cAMP‐dependent protein kinase (PKA), and phosphatidylinositol 3‐kinase (PI3K) regulate nemertean GVBD, oocytes of Cerebratulus sp. were treated with pharmacological modulators and stimulated with cAMP‐elevating drugs or seawater (SW) alone. Both cAMP elevators and SW triggered GVBD while activating MAPK, its target p90Rsk, and MPF. Similarly, neither cAMP‐ nor SW‐induced GVBD was affected by several Ser/Thr phosphatase inhibitors, and both stimuli apparently accelerated GVBD via a MAPK‐independent, PI3K‐dependent mechanism. However, inhibitors of Raf‐1, a kinase that activates MAPK kinase, blocked GVBD and MAPK activation during SW‐, but not cAMP‐induced maturation. In addition, MPF blockers more effectively reduced GVBD and MAPK activity in SW versus in cAMP‐elevating treatments. Moreover, the two maturation‐inducing stimuli yielded disparate patterns of PKA‐related MAPK activations and phosphorylations of putative PKA substrates. Collectively, such findings suggest that in maturing oocytes of Cerebratulus sp., Ser/Thr kinase cascades differ during cAMP‐ versus SW‐induced GVBD in several ways, including MAPK activation modes, MPF‐feedback loops, and PKA‐related signaling pathways. Additional differences in cAMP‐ versus SW‐induced oocyte maturation are also described in the accompanying study that deals with the roles of tyrosine kinase signaling during GVBD. Mol. Reprod. Dev. 73: 1578–1590, 2006. © 2006 Wiley‐Liss, Inc." @default.
• W2156988210 created "2016-06-24" @default.
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• W2156988210 date "2006-09-19" @default.
• W2156988210 modified "2023-10-17" @default.
• W2156988210 title "Differing mechanisms of cAMP- versus seawater-induced oocyte maturation in marine nemertean worms I. The roles of serine/threonine kinases and phosphatases" @default.
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• W2156988210 doi "https://doi.org/10.1002/mrd.20597" @default.
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