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- W2156988770 abstract "Abstract Phosphatidylinositol-specific phospholipases (PI-PLCs) are virulence factors produced by many pathogenic bacteria, including Bacillus anthracis and Listeria monocytogenes. Bacillus PI-PLC differs from Listeria PI-PLC in that it has strong activity for cleaving GPI-anchored proteins. Treatment of murine DCs with Bacillus, but not Listeria, PI-PLC inhibited dendritic cell (DC) activation by TLR ligands. Infection of mice with Listeria expressing B. anthracis PI-PLC resulted in a reduced Ag-specific CD4 T cell response. These data indicate that B. anthracis PI-PLC down-modulates DC function and T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated DC activation." @default.
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- W2156988770 date "2005-06-15" @default.
- W2156988770 modified "2023-10-12" @default.
- W2156988770 title "Phosphatidylinositol-Specific Phospholipase C of<i>Bacillus anthracis</i>Down-Modulates the Immune Response" @default.
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- W2156988770 doi "https://doi.org/10.4049/jimmunol.174.12.8011" @default.
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