FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156996453> ?p ?o ?g. }

• W2156996453 endingPage "702" @default.
• W2156996453 startingPage "692" @default.
• W2156996453 abstract "Drug abuse and addiction are excessively common in schizophrenia. Chronic antipsychotic treatment might contribute to this comorbidity by inducing supersensitivity within the brain's dopamine system. Dopamine supersensitivity can enhance the incentive motivational properties of reward cues, and reward cues contribute to the maintenance and severity of drug addiction. We have shown previously that rats withdrawn from continuous haloperidol (HAL) treatment (via subcutaneous minipump) develop dopamine supersensitivity and pursue reward cues more vigorously than HAL-naive rats following an amphetamine (AMPH) challenge. Atypical antipsychotic drugs are thought to be less likely than typicals to produce dopamine supersensitivity. Thus, we compared the effects of HAL and the atypical antipsychotic olanzapine (OLZ) on the pursuit of reward cues. Rats were trained to associate a light-tone cue with water then treated with HAL or OLZ. Following antipsychotic withdrawal, we assessed AMPH-induced enhancement of lever pressing for the cue. Withdrawal from HAL, but not from OLZ, enhanced this effect. HAL, but not OLZ, also enhanced AMPH-induced psychomotor activation and c-fos mRNA expression in the caudate-putamen. Thus, prior HAL, but not OLZ, enhanced conditioned reward following an AMPH challenge, and this was potentially linked to enhanced behavioral sensitivity to AMPH and AMPH-induced engagement of the caudate-putamen. These findings suggest that HAL, but not an atypical like OLZ, modifies reward circuitry in ways that increase responsiveness to reward cues. Because enhanced responsiveness to reward cues can promote drug-seeking behavior, it should be investigated whether atypical antipsychotics might be a preferential option in schizophrenic patients at risk for drug abuse or addiction." @default.
• W2156996453 created "2016-06-24" @default.
• W2156996453 creator A5062428230 @default.
• W2156996453 creator A5064679250 @default.
• W2156996453 creator A5065146020 @default.
• W2156996453 creator A5007219466 @default.
• W2156996453 date "2012-08-27" @default.
• W2156996453 modified "2023-10-16" @default.
• W2156996453 title "Prior Haloperidol, but not Olanzapine, Exposure Augments the Pursuit of Reward Cues: Implications for Substance Abuse in Schizophrenia" @default.
• W2156996453 cites W1629537514 @default.
• W2156996453 cites W1966533004 @default.
• W2156996453 cites W1968013284 @default.
• W2156996453 cites W1968122997 @default.
• W2156996453 cites W1971165967 @default.
• W2156996453 cites W1973313963 @default.
• W2156996453 cites W1975417628 @default.
• W2156996453 cites W1976602152 @default.
• W2156996453 cites W1978863100 @default.
• W2156996453 cites W1999170649 @default.
• W2156996453 cites W1999646972 @default.
• W2156996453 cites W2000915741 @default.
• W2156996453 cites W2001837815 @default.
• W2156996453 cites W2003033559 @default.
• W2156996453 cites W2006406883 @default.
• W2156996453 cites W2008902227 @default.
• W2156996453 cites W2012129826 @default.
• W2156996453 cites W2013460039 @default.
• W2156996453 cites W2017966418 @default.
• W2156996453 cites W2018742347 @default.
• W2156996453 cites W2026781531 @default.
• W2156996453 cites W2029986826 @default.
• W2156996453 cites W2038409107 @default.
• W2156996453 cites W2040903782 @default.
• W2156996453 cites W2046346017 @default.
• W2156996453 cites W2047422895 @default.
• W2156996453 cites W2050368052 @default.
• W2156996453 cites W2053409990 @default.
• W2156996453 cites W2053717786 @default.
• W2156996453 cites W2055240237 @default.
• W2156996453 cites W2062134604 @default.
• W2156996453 cites W2072069319 @default.
• W2156996453 cites W2078396129 @default.
• W2156996453 cites W2080238922 @default.
• W2156996453 cites W2083143542 @default.
• W2156996453 cites W2083861264 @default.
• W2156996453 cites W2084461965 @default.
• W2156996453 cites W2085188760 @default.
• W2156996453 cites W2086745845 @default.
• W2156996453 cites W2093757762 @default.
• W2156996453 cites W2099185967 @default.
• W2156996453 cites W2120718153 @default.
• W2156996453 cites W2123497470 @default.
• W2156996453 cites W2142151511 @default.
• W2156996453 cites W2146934197 @default.
• W2156996453 cites W2153437292 @default.
• W2156996453 cites W2160315491 @default.
• W2156996453 cites W2165385583 @default.
• W2156996453 cites W2317279774 @default.
• W2156996453 cites W4294307687 @default.
• W2156996453 cites W45776812 @default.
• W2156996453 doi "https://doi.org/10.1093/schbul/sbs077" @default.
• W2156996453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627770" @default.
• W2156996453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22927669" @default.
• W2156996453 hasPublicationYear "2012" @default.
• W2156996453 type Work @default.
• W2156996453 sameAs 2156996453 @default.
• W2156996453 citedByCount "24" @default.
• W2156996453 countsByYear W21569964532013 @default.
• W2156996453 countsByYear W21569964532014 @default.
• W2156996453 countsByYear W21569964532015 @default.
• W2156996453 countsByYear W21569964532016 @default.
• W2156996453 countsByYear W21569964532017 @default.
• W2156996453 countsByYear W21569964532018 @default.
• W2156996453 countsByYear W21569964532020 @default.
• W2156996453 countsByYear W21569964532021 @default.
• W2156996453 countsByYear W21569964532022 @default.
• W2156996453 crossrefType "journal-article" @default.
• W2156996453 hasAuthorship W2156996453A5007219466 @default.
• W2156996453 hasAuthorship W2156996453A5062428230 @default.
• W2156996453 hasAuthorship W2156996453A5064679250 @default.
• W2156996453 hasAuthorship W2156996453A5065146020 @default.
• W2156996453 hasBestOaLocation W21569964531 @default.
• W2156996453 hasConcept C118552586 @default.
• W2156996453 hasConcept C15744967 @default.
• W2156996453 hasConcept C169760540 @default.
• W2156996453 hasConcept C2776412080 @default.
• W2156996453 hasConcept C2776619155 @default.
• W2156996453 hasConcept C2777193897 @default.
• W2156996453 hasConcept C2780494398 @default.
• W2156996453 hasConcept C2780948584 @default.
• W2156996453 hasConcept C48856860 @default.
• W2156996453 hasConcept C513476851 @default.
• W2156996453 hasConcept C71924100 @default.
• W2156996453 hasConcept C98274493 @default.
• W2156996453 hasConceptScore W2156996453C118552586 @default.
• W2156996453 hasConceptScore W2156996453C15744967 @default.
• W2156996453 hasConceptScore W2156996453C169760540 @default.
• W2156996453 hasConceptScore W2156996453C2776412080 @default.

• next