FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157008633> ?p ?o ?g. }

• W2157008633 endingPage "18" @default.
• W2157008633 startingPage "11" @default.
• W2157008633 abstract "Abstract: Until recently, chimpanzees were considered susceptible to human immunodeficiency virus type 1 (HIV‐1) infection, but refractory to disease induction based on the asymptomatic status of all experimentally infected chimpanzees after over 10 years postinfection (PI). However, a decline in peripheral CD4 + T cells was noted in one chimpanzee (C499) of the Yerkes cohort of HIV‐1 infected apes, after 11 years PI concurrent with increasing plasma viral load. These clinical signs were followed by the occurrence of opportunistic infections, thrombocytopenia, and progressive anemia leading to euthanasia. A second chimpanzee (C455) was transfused with blood from C499 collected during the symptomatic stage. Shortly thereafter, this second animal showed a rapid decline in peripheral CD4 + T‐cell levels and sustained high viral load. Hematological analyses showed a 50% decrease in CFU‐GM for both apes during the symptomatic phase and a reduction of 40% and 73% of the total CFU despite normal levels of CD34 + cells in the bone marrow. Cryopreserved sequential PBMC samples from these two chimpanzees were analyzed for constitutive and PHA‐P induced levels of cytokines and chemokines. Data show that whereas there were no detectable constitutive levels of mRNA coding for IL‐2, 4, and 10, there appears to be a transient increase in IFN‐γ message level coincident with increased viremia and this IFN‐γ synthesis decreased with disease progression. PHA‐induced cytokine mRNA analysis showed low or undetectable levels of IL‐4 and IL‐10 mRNA in all samples and a marked decrease in the levels of IL‐2 shortly after HIV infection. In addition, there was also a gradual decrease in IFN‐y mRNA with progression of disease. Of interest were the findings of high to normal levels of PHA‐induced synthesis of the chemokines MIP‐1γ, MIP‐1β, and RANTES in samples during the asymptomatic and early symptomatic period, which also dramatically decreased at late stages of the disease. These data suggest important roles for IL‐2, IFN‐γ, and the chemokines in the regulation of immune responses in HIV‐1‐infected chimpanzees." @default.
• W2157008633 created "2016-06-24" @default.
• W2157008633 creator A5002053094 @default.
• W2157008633 creator A5009543374 @default.
• W2157008633 creator A5033318169 @default.
• W2157008633 creator A5036306540 @default.
• W2157008633 creator A5041092935 @default.
• W2157008633 creator A5041763125 @default.
• W2157008633 creator A5059198551 @default.
• W2157008633 creator A5064153887 @default.
• W2157008633 creator A5087925525 @default.
• W2157008633 date "1997-02-04" @default.
• W2157008633 modified "2023-09-23" @default.
• W2157008633 title "Immune and hematopoietic parameters in HIV-1-infected chimpanzees during clinical progression toward AIDS" @default.
• W2157008633 cites W1490975533 @default.
• W2157008633 cites W1508657985 @default.
• W2157008633 cites W1517442674 @default.
• W2157008633 cites W1519760373 @default.
• W2157008633 cites W1622334622 @default.
• W2157008633 cites W1934588590 @default.
• W2157008633 cites W1965019797 @default.
• W2157008633 cites W1965228684 @default.
• W2157008633 cites W1981183434 @default.
• W2157008633 cites W1981644527 @default.
• W2157008633 cites W1984811742 @default.
• W2157008633 cites W1989035987 @default.
• W2157008633 cites W1996183144 @default.
• W2157008633 cites W1999924194 @default.
• W2157008633 cites W2005200639 @default.
• W2157008633 cites W2010058254 @default.
• W2157008633 cites W2027016157 @default.
• W2157008633 cites W2027570953 @default.
• W2157008633 cites W2030902226 @default.
• W2157008633 cites W2040868302 @default.
• W2157008633 cites W2042100935 @default.
• W2157008633 cites W2044381195 @default.
• W2157008633 cites W2056224227 @default.
• W2157008633 cites W2060333964 @default.
• W2157008633 cites W2064545368 @default.
• W2157008633 cites W2068838995 @default.
• W2157008633 cites W2085161097 @default.
• W2157008633 cites W2090356138 @default.
• W2157008633 cites W2111704944 @default.
• W2157008633 cites W2122238978 @default.
• W2157008633 cites W2131376910 @default.
• W2157008633 cites W2135941019 @default.
• W2157008633 cites W2170206314 @default.
• W2157008633 cites W83564348 @default.
• W2157008633 cites W2068400788 @default.
• W2157008633 doi "https://doi.org/10.1111/j.1600-0684.1997.tb00314.x" @default.
• W2157008633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9271184" @default.
• W2157008633 hasPublicationYear "1997" @default.
• W2157008633 type Work @default.
• W2157008633 sameAs 2157008633 @default.
• W2157008633 citedByCount "23" @default.
• W2157008633 countsByYear W21570086332015 @default.
• W2157008633 countsByYear W21570086332019 @default.
• W2157008633 crossrefType "journal-article" @default.
• W2157008633 hasAuthorship W2157008633A5002053094 @default.
• W2157008633 hasAuthorship W2157008633A5009543374 @default.
• W2157008633 hasAuthorship W2157008633A5033318169 @default.
• W2157008633 hasAuthorship W2157008633A5036306540 @default.
• W2157008633 hasAuthorship W2157008633A5041092935 @default.
• W2157008633 hasAuthorship W2157008633A5041763125 @default.
• W2157008633 hasAuthorship W2157008633A5059198551 @default.
• W2157008633 hasAuthorship W2157008633A5064153887 @default.
• W2157008633 hasAuthorship W2157008633A5087925525 @default.
• W2157008633 hasConcept C109159458 @default.
• W2157008633 hasConcept C126322002 @default.
• W2157008633 hasConcept C13373296 @default.
• W2157008633 hasConcept C137061746 @default.
• W2157008633 hasConcept C142462285 @default.
• W2157008633 hasConcept C159047783 @default.
• W2157008633 hasConcept C202751555 @default.
• W2157008633 hasConcept C203014093 @default.
• W2157008633 hasConcept C2522874641 @default.
• W2157008633 hasConcept C2776185481 @default.
• W2157008633 hasConcept C2777910003 @default.
• W2157008633 hasConcept C2778690821 @default.
• W2157008633 hasConcept C2780007613 @default.
• W2157008633 hasConcept C28328180 @default.
• W2157008633 hasConcept C54355233 @default.
• W2157008633 hasConcept C55493867 @default.
• W2157008633 hasConcept C71924100 @default.
• W2157008633 hasConcept C86803240 @default.
• W2157008633 hasConcept C8891405 @default.
• W2157008633 hasConceptScore W2157008633C109159458 @default.
• W2157008633 hasConceptScore W2157008633C126322002 @default.
• W2157008633 hasConceptScore W2157008633C13373296 @default.
• W2157008633 hasConceptScore W2157008633C137061746 @default.
• W2157008633 hasConceptScore W2157008633C142462285 @default.
• W2157008633 hasConceptScore W2157008633C159047783 @default.
• W2157008633 hasConceptScore W2157008633C202751555 @default.
• W2157008633 hasConceptScore W2157008633C203014093 @default.
• W2157008633 hasConceptScore W2157008633C2522874641 @default.
• W2157008633 hasConceptScore W2157008633C2776185481 @default.
• W2157008633 hasConceptScore W2157008633C2777910003 @default.
• W2157008633 hasConceptScore W2157008633C2778690821 @default.

• next