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• W2157015322 abstract "There is evidence that most alterations in inotropic state occurring under normal circumstances do not substantially influence diastolic compliance, except perhaps in the rapid phases of cardiac filling. Nevertheless, recent studies have clearly shown that left ventricular compliance can be markedly altered in chronic disease states, acute myocardial infarction, chronic ventricular hypertrophy and failure and chronic dilatation influencing diastolic compliance in an important manner. The large shift to the right of the pressure-volume relation observed in the chronically dilated left ventricle allows the ventricle to operate from a large radius and to deliver a normal or increased stroke volume without a great increase in end-diastolic pressure. On the other hand, the decrease in compliance without a shift to the right that appears to occur in acute myocardial infarction may increase filling pressure without this mechanical advantage and be detrimental. The question of when and by what mechanism changes in heart size and compliance appear to become irreversible seems to be amenable to experimental study and could have important clinical implications. It is suggested that one appropriate way to evaluate chronic changes in cardiac compliance is to assess the diastolic pressure-volume relation or the pressure-circumference relation over a range of pressures up to end-diastolic pressure, or over the range of volume accompanying the stroke volume. This approach, encompassing a normal cardiac filling cycle, and defined as functional compliance, should offer useful clinical information on the filling characteristics of the ventricle relative to pressures transmitted in retrograde manner to the lungs or the systemic venous circulation. The assessment of the passive stress-strain relation of the myocardium itself in the whole heart remains a difficult and challenging problem." @default.
• W2157015322 created "2016-06-24" @default.
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• W2157015322 date "1973-09-01" @default.
• W2157015322 modified "2023-09-24" @default.
• W2157015322 title "Nature and significance of alterations in myocardial compliance" @default.
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• W2157015322 doi "https://doi.org/10.1016/s0002-9149(73)80035-9" @default.
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