FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157032204> ?p ?o ?g. }

• W2157032204 endingPage "782" @default.
• W2157032204 startingPage "773" @default.
• W2157032204 abstract "Pertussis toxin (PTX) is an AB5-type exotoxin produced by the bacterium Bordetella pertussis, the causative agent of whooping cough. In vivo intoxication with PTX elicits a variety of immunologic and inflammatory responses, including vasoactive amine sensitization (VAAS) to histamine (HA), serotonin (5-HT), and bradykinin (BDK). Previously, by using a forward genetic approach, we identified the HA H1 receptor (Hrh1/H1R) as the gene in mice that controls differential susceptibility to B. pertussis PTX-induced HA sensitization (Bphs). Here we show, by using inbred strains of mice, F1 hybrids, and segregating populations, that, unlike Bphs, PTX-induced 5-HT sensitivity (Bpss) and BDK sensitivity (Bpbs) are recessive traits and are separately controlled by multiple loci unlinked to 5-HT and BDK receptors, respectively. Furthermore, we found that PTX sensitizes mice to HA independently of Toll-like receptor 4, a purported receptor for PTX, and that the VAAS properties of PTX are not dependent upon endothelial caveolae or endothelial nitric oxide synthase. Finally, by using mice deficient in individual Gαi/o G-protein subunits, we demonstrate that Gαi1 and Gαi3 are the critical in vivo targets of ADP-ribosylation underlying VAAS elicited by PTX exposure." @default.
• W2157032204 created "2016-06-24" @default.
• W2157032204 creator A5010892509 @default.
• W2157032204 creator A5020278864 @default.
• W2157032204 creator A5052335606 @default.
• W2157032204 creator A5057712921 @default.
• W2157032204 creator A5071657531 @default.
• W2157032204 creator A5071923817 @default.
• W2157032204 creator A5090816940 @default.
• W2157032204 date "2014-02-01" @default.
• W2157032204 modified "2023-10-05" @default.
• W2157032204 title "G Proteins Gα_i1/3Are Critical Targets for Bordetella pertussis Toxin-Induced Vasoactive Amine Sensitization" @default.
• W2157032204 cites W1492105728 @default.
• W2157032204 cites W1508249425 @default.
• W2157032204 cites W1527489726 @default.
• W2157032204 cites W1543967583 @default.
• W2157032204 cites W1556103840 @default.
• W2157032204 cites W1560983797 @default.
• W2157032204 cites W157315 @default.
• W2157032204 cites W1573946811 @default.
• W2157032204 cites W1595775068 @default.
• W2157032204 cites W1643087207 @default.
• W2157032204 cites W1830814020 @default.
• W2157032204 cites W1946571358 @default.
• W2157032204 cites W1955200347 @default.
• W2157032204 cites W1971977052 @default.
• W2157032204 cites W1972447401 @default.
• W2157032204 cites W1975998142 @default.
• W2157032204 cites W1978431351 @default.
• W2157032204 cites W1986913568 @default.
• W2157032204 cites W1987525020 @default.
• W2157032204 cites W1993746949 @default.
• W2157032204 cites W1994810222 @default.
• W2157032204 cites W1995263870 @default.
• W2157032204 cites W1998367850 @default.
• W2157032204 cites W2005614924 @default.
• W2157032204 cites W2006958729 @default.
• W2157032204 cites W2012528572 @default.
• W2157032204 cites W2014567202 @default.
• W2157032204 cites W2020869636 @default.
• W2157032204 cites W2024469556 @default.
• W2157032204 cites W2026756636 @default.
• W2157032204 cites W2027840218 @default.
• W2157032204 cites W2032651182 @default.
• W2157032204 cites W2047425163 @default.
• W2157032204 cites W2052446038 @default.
• W2157032204 cites W2052773849 @default.
• W2157032204 cites W2054586855 @default.
• W2157032204 cites W2056239892 @default.
• W2157032204 cites W2057399882 @default.
• W2157032204 cites W2067441205 @default.
• W2157032204 cites W2068016581 @default.
• W2157032204 cites W2068117750 @default.
• W2157032204 cites W2072799387 @default.
• W2157032204 cites W2075515543 @default.
• W2157032204 cites W2079738723 @default.
• W2157032204 cites W2079740701 @default.
• W2157032204 cites W2081202846 @default.
• W2157032204 cites W2083820494 @default.
• W2157032204 cites W2088563557 @default.
• W2157032204 cites W2091181468 @default.
• W2157032204 cites W2091499945 @default.
• W2157032204 cites W2092404377 @default.
• W2157032204 cites W2092536433 @default.
• W2157032204 cites W2102140340 @default.
• W2157032204 cites W2102549434 @default.
• W2157032204 cites W2102773142 @default.
• W2157032204 cites W2103065509 @default.
• W2157032204 cites W2104209099 @default.
• W2157032204 cites W2104969843 @default.
• W2157032204 cites W2106112598 @default.
• W2157032204 cites W2108988641 @default.
• W2157032204 cites W2110246883 @default.
• W2157032204 cites W2122474832 @default.
• W2157032204 cites W2123313053 @default.
• W2157032204 cites W2125797445 @default.
• W2157032204 cites W2129319296 @default.
• W2157032204 cites W2129535012 @default.
• W2157032204 cites W2136371196 @default.
• W2157032204 cites W2145022795 @default.
• W2157032204 cites W2156921663 @default.
• W2157032204 cites W2158595527 @default.
• W2157032204 cites W2159252214 @default.
• W2157032204 cites W2165705942 @default.
• W2157032204 cites W2169617094 @default.
• W2157032204 cites W2171863036 @default.
• W2157032204 cites W229669863 @default.
• W2157032204 cites W4237106186 @default.
• W2157032204 cites W4239644485 @default.
• W2157032204 cites W4253413288 @default.
• W2157032204 doi "https://doi.org/10.1128/iai.00971-13" @default.
• W2157032204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3911370" @default.
• W2157032204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24478091" @default.
• W2157032204 hasPublicationYear "2014" @default.
• W2157032204 type Work @default.
• W2157032204 sameAs 2157032204 @default.
• W2157032204 citedByCount "13" @default.
• W2157032204 countsByYear W21570322042015 @default.

• next