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- W2157037358 abstract "Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (p<0.01), and was higher in brain-invasive meningiomas compared to non-invasive meningiomas (WHO grade I) (p<0.05). Furthermore, the expression of Vav3, p-Akt, and Ki-67 was higher in recurrent meningiomas compared to non-recurrent meningiomas (WHO grade I) (p<0.05).The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence.Expression de SPARC et de Vav3 dans le méningiome : facteurs reliés au pronostic." @default.
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- W2157037358 date "2013-11-01" @default.
- W2157037358 modified "2023-10-14" @default.
- W2157037358 title "SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis" @default.
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- W2157037358 doi "https://doi.org/10.1017/s0317167100015948" @default.
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