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• W2157076853 endingPage "1518" @default.
• W2157076853 startingPage "1511" @default.
• W2157076853 abstract "Cigarette smoke (CS) contains several carcinogens known to initiate and promote tumorigenesis and metastasis. Because various genes that mediate carcinogenesis and tumorigenesis are regulated by nuclear factor-κB (NF-κB), we postulated that the effects of CS must be mediated through activation of this transcription factor. Therefore, in the present report we investigated whether cigarette smoke condensate (CSC) activates NF-κB, and whether the pathway employed for activation is similar to that of TNF, one of the potent activators of NF-κB. Our results show that the treatment of human histiocytic lymphoma U-937 cells with CSC activated NF-κB in a dose- and time-dependent manner. The kinetics of NF-κB activation by CSC was comparable with that of TNF. CSC-induced NF-κB activation was not cell type-specific, as it also activated NF-κB in T cells (Jurkat), lung cells (H1299), and head and neck squamous cell lines (1483 and 14B). Activation of NF-κB by CSC correlated with time-dependent degradation of IκBα, an inhibitor of NF-κB. Further studies revealed that CSC induced phosphorylation of the serine residue at position 32 in IκBα. In vitro immunocomplex kinase assays showed that CSC activated IκBα kinase (IKK). The suppression of CSC-activated NF-κB-dependent reporter gene expression by dominant negative form of IκBα, TRAF2, NIK and IKK suggests a similarity to the TNF-induced pathway for NF-κB. CSC also induced the expression of cyclooxygenase-2, an NF-κB regulated gene product. Overall, our results indicate that through phosphorylation and degradation of IκBα, CSC can activate NF-κB in a wide a variety of cells, and this may play a role in CS-induced carcinogenesis." @default.
• W2157076853 created "2016-06-24" @default.
• W2157076853 creator A5048675624 @default.
• W2157076853 creator A5053960002 @default.
• W2157076853 creator A5065164142 @default.
• W2157076853 creator A5073531521 @default.
• W2157076853 creator A5085218671 @default.
• W2157076853 date "2002-09-01" @default.
• W2157076853 modified "2023-10-06" @default.
• W2157076853 title "Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaBalpha: correlation with induction of cyclooxygenase-2" @default.
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• W2157076853 cites W1538376958 @default.
• W2157076853 cites W1557884422 @default.
• W2157076853 cites W1589234645 @default.
• W2157076853 cites W1592752790 @default.
• W2157076853 cites W1595942511 @default.
• W2157076853 cites W1965122471 @default.
• W2157076853 cites W1965404141 @default.
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• W2157076853 cites W1976056213 @default.
• W2157076853 cites W1977394772 @default.
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• W2157076853 doi "https://doi.org/10.1093/carcin/23.9.1511" @default.
• W2157076853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12189195" @default.
• W2157076853 hasPublicationYear "2002" @default.
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