FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157079783> ?p ?o ?g. }

• W2157079783 endingPage "919" @default.
• W2157079783 startingPage "913" @default.
• W2157079783 abstract "Abstract Recent publications have provided confusing information on the importance of the J chain for secretion of dimeric IgA at mucosal surfaces. Using J chain-deficient (J chain−/−) mice, we addressed whether a lack of J chain had any functional consequence for the ability to resist challenge with cholera toxin (CT) in intestinal loops. J chain−/− mice had normal levels of IgA plasma cells in the gut mucosa, and the Peyer’s patches exhibited normal IgA B cell differentiation and germinal center reactions. The total IgA levels in gut lavage were reduced by roughly 90% as compared with that in wild-type controls, while concomitantly serum IgA levels were significantly increased. Total serum IgM levels were depressed, whereas IgG concentrations were normal. Following oral immunizations with CT, J chain−/− mice developed 10-fold increased serum antitoxin IgA titers, but gut lavage anti-CT IgA levels were substantially reduced. However, anti-CT IgA spot-forming cell frequencies in the gut lamina propria were normal. Anti-CT IgM concentrations were low in serum and gut lavage, whereas anti-CT IgG titers were unaltered. Challenge of small intestinal ligated loops with CT caused dramatic fluid accumulation in immunized J chain−/− mice, and only 20% protection was detected compared with unimmunized controls. In contrast, wild-type mice demonstrated 80% protection against CT challenge. Mice heterozygous for the J chain deletion exhibited intermediate gut lavage anti-CT IgA and intestinal protection levels, arguing for a J chain gene-dosage effect on the transport of secretory IgA. This study unequivocally demonstrates a direct relationship between mucosal transport of secretory SIgA and intestinal immune protection." @default.
• W2157079783 created "2016-06-24" @default.
• W2157079783 creator A5009771424 @default.
• W2157079783 creator A5022616402 @default.
• W2157079783 creator A5057883319 @default.
• W2157079783 creator A5076016480 @default.
• W2157079783 creator A5091062006 @default.
• W2157079783 date "1999-07-15" @default.
• W2157079783 modified "2023-10-09" @default.
• W2157079783 title "Lack of J Chain Inhibits the Transport of Gut IgA and Abrogates the Development of Intestinal Antitoxic Protection" @default.
• W2157079783 cites W1517886084 @default.
• W2157079783 cites W1548367056 @default.
• W2157079783 cites W1772959897 @default.
• W2157079783 cites W1821658953 @default.
• W2157079783 cites W1868719995 @default.
• W2157079783 cites W1901787455 @default.
• W2157079783 cites W1919984851 @default.
• W2157079783 cites W1964786677 @default.
• W2157079783 cites W1983826199 @default.
• W2157079783 cites W2011257622 @default.
• W2157079783 cites W2013167867 @default.
• W2157079783 cites W2027731856 @default.
• W2157079783 cites W2050656853 @default.
• W2157079783 cites W2055851901 @default.
• W2157079783 cites W2059124791 @default.
• W2157079783 cites W2062211532 @default.
• W2157079783 cites W2069640108 @default.
• W2157079783 cites W2072895436 @default.
• W2157079783 cites W2080071424 @default.
• W2157079783 cites W2090220728 @default.
• W2157079783 cites W2102873986 @default.
• W2157079783 cites W2104738744 @default.
• W2157079783 cites W2117439482 @default.
• W2157079783 cites W2121791329 @default.
• W2157079783 cites W2159499713 @default.
• W2157079783 cites W2186360180 @default.
• W2157079783 cites W4229682969 @default.
• W2157079783 doi "https://doi.org/10.4049/jimmunol.163.2.913" @default.
• W2157079783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10395687" @default.
• W2157079783 hasPublicationYear "1999" @default.
• W2157079783 type Work @default.
• W2157079783 sameAs 2157079783 @default.
• W2157079783 citedByCount "97" @default.
• W2157079783 countsByYear W21570797832012 @default.
• W2157079783 countsByYear W21570797832013 @default.
• W2157079783 countsByYear W21570797832014 @default.
• W2157079783 countsByYear W21570797832015 @default.
• W2157079783 countsByYear W21570797832016 @default.
• W2157079783 countsByYear W21570797832017 @default.
• W2157079783 countsByYear W21570797832018 @default.
• W2157079783 countsByYear W21570797832019 @default.
• W2157079783 countsByYear W21570797832020 @default.
• W2157079783 countsByYear W21570797832022 @default.
• W2157079783 countsByYear W21570797832023 @default.
• W2157079783 crossrefType "journal-article" @default.
• W2157079783 hasAuthorship W2157079783A5009771424 @default.
• W2157079783 hasAuthorship W2157079783A5022616402 @default.
• W2157079783 hasAuthorship W2157079783A5057883319 @default.
• W2157079783 hasAuthorship W2157079783A5076016480 @default.
• W2157079783 hasAuthorship W2157079783A5091062006 @default.
• W2157079783 hasBestOaLocation W21570797831 @default.
• W2157079783 hasConcept C126322002 @default.
• W2157079783 hasConcept C134018914 @default.
• W2157079783 hasConcept C159654299 @default.
• W2157079783 hasConcept C203014093 @default.
• W2157079783 hasConcept C2777006276 @default.
• W2157079783 hasConcept C2777310793 @default.
• W2157079783 hasConcept C2777367657 @default.
• W2157079783 hasConcept C2778973234 @default.
• W2157079783 hasConcept C2779102806 @default.
• W2157079783 hasConcept C2780898057 @default.
• W2157079783 hasConcept C3019368612 @default.
• W2157079783 hasConcept C32611913 @default.
• W2157079783 hasConcept C529295009 @default.
• W2157079783 hasConcept C54355233 @default.
• W2157079783 hasConcept C71924100 @default.
• W2157079783 hasConcept C86803240 @default.
• W2157079783 hasConcept C8891405 @default.
• W2157079783 hasConcept C89423630 @default.
• W2157079783 hasConcept C97615245 @default.
• W2157079783 hasConceptScore W2157079783C126322002 @default.
• W2157079783 hasConceptScore W2157079783C134018914 @default.
• W2157079783 hasConceptScore W2157079783C159654299 @default.
• W2157079783 hasConceptScore W2157079783C203014093 @default.
• W2157079783 hasConceptScore W2157079783C2777006276 @default.
• W2157079783 hasConceptScore W2157079783C2777310793 @default.
• W2157079783 hasConceptScore W2157079783C2777367657 @default.
• W2157079783 hasConceptScore W2157079783C2778973234 @default.
• W2157079783 hasConceptScore W2157079783C2779102806 @default.
• W2157079783 hasConceptScore W2157079783C2780898057 @default.
• W2157079783 hasConceptScore W2157079783C3019368612 @default.
• W2157079783 hasConceptScore W2157079783C32611913 @default.
• W2157079783 hasConceptScore W2157079783C529295009 @default.
• W2157079783 hasConceptScore W2157079783C54355233 @default.
• W2157079783 hasConceptScore W2157079783C71924100 @default.
• W2157079783 hasConceptScore W2157079783C86803240 @default.
• W2157079783 hasConceptScore W2157079783C8891405 @default.
• W2157079783 hasConceptScore W2157079783C89423630 @default.

• next