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- W2157090777 abstract "Brain metastases are a major clinical problem in patients with advanced breast cancer, lung cancer, melanoma, and renal cell carcinoma. Initial treatment for patients with brain metastases typically includes radiotherapy, either whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), or both. Surgical resection is generally reserved for good prognosis patients with limited/controlled extracranial metastases and a single brain lesion. Once patients progress through upfront treatment, the treatment approach is quite variable and there is no clearly defined standard-of-care. Over the past decade, the role of systemic therapies and in particular, targeted therapies has been increasingly explored in patients with brain metastases from solid tumors. For example, lapatinib has been studied as monotherapy, and in combination with capecitabine, in patients with HER2-positive breast cancer, and activity has been observed in both the upfront and refractory settings. In patients with nonsmall cell lung cancer (NSCLC), central nervous system (CNS) activity has been reported with gefinitib and erlotinib. Finally, in melanoma, the B-raf inhibitors vemurafenib and dabrafenib, and the immunomodulator, ipilumimab, have reported CNS activity. Moving forward, the challenge will be to understand how to optimize the activity of targeted agents in the CNS and how to best incorporate them into the current treatment paradigms in order to improve outcomes for this patient population." @default.
- W2157090777 created "2016-06-24" @default.
- W2157090777 creator A5049174232 @default.
- W2157090777 date "2013-12-19" @default.
- W2157090777 modified "2023-10-16" @default.
- W2157090777 title "Targeted Therapies in Brain Metastases" @default.
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- W2157090777 doi "https://doi.org/10.1007/s11940-013-0276-z" @default.
- W2157090777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3895218" @default.
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