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• W2157100007 abstract "Autophagy is an evolutionarily conserved catabolic process that involves the engulfment of cytoplasmic contents in a closed double-membrane structure, called the autophagosome, and their subsequent delivery to the vacuole/lysosomes for degradation. Genetic screens in Saccharomyces cerevisiae have identified more than 30 autophagy-related (Atg) genes that are essential for autophagosome formation. Here we isolated a novel autophagy gene, epg-9, whose loss of function causes defective autophagic degradation of a variety of protein aggregates during C. elegans embryogenesis. Mutations in epg-9 also reduce survival of animals under food depletion conditions. epg-9 mutants exhibit autophagy phenotypes characteristic of those associated with loss of function of unc-51/Atg1 and epg-1/Atg13. epg-9 encodes a protein with significant homology to mammalian ATG101. EPG-9 directly interacts with EPG-1/Atg13. Our study indicates that EPG-9 forms a complex with EPG-1 in the aggrephagy pathway in C. elegans." @default.
• W2157100007 created "2016-06-24" @default.
• W2157100007 creator A5001230731 @default.
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• W2157100007 date "2012-10-16" @default.
• W2157100007 modified "2023-10-16" @default.
• W2157100007 title "The<i>C. elegans</i>ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy" @default.
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• W2157100007 doi "https://doi.org/10.4161/auto.21163" @default.
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• W2157100007 hasPublicationYear "2012" @default.
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