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- W2157101941 abstract "Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)alpha is a central transcriptional suppressor of inflammation, and may therefore modulate tumor growth. Here we show that PPARalpha deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of the endogenous angiogenesis inhibitor thrombospondin-1 and prevents tumor growth. Bone marrow transplantation and granulocyte depletion show that PPARalpha expressing granulocytes are necessary for tumor growth. Neutralization of thrombospondin-1 restores tumor growth in PPARalpha-deficient mice. These findings suggest that the absence of PPARalpha activity renders inflammatory infiltrates tumor suppressive and, thus, may provide a target for inhibiting tumor growth by modulating stromal processes, such as angiogenesis." @default.
- W2157101941 created "2016-06-24" @default.
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- W2157101941 date "2007-02-28" @default.
- W2157101941 modified "2023-10-16" @default.
- W2157101941 title "PPARα Deficiency in Inflammatory Cells Suppresses Tumor Growth" @default.
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- W2157101941 doi "https://doi.org/10.1371/journal.pone.0000260" @default.
- W2157101941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1800345" @default.
- W2157101941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17327920" @default.
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