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- W2157149369 abstract "Background Talc is the most effective chemical pleurodesis agent for patients with malignant pleural effusion. However, concerns have arisen about the safety of intrapleural application of talc, after reports of development of acute respiratory distress syndrome in 1–9% of treated patients. Our aim was to establish whether use of large-particle-size talc is safe in patients with malignant pleural effusion. Methods We did a multicentre, open-label, prospective cohort study of 558 patients with malignant pleural effusion who underwent thoracoscopy and talc poudrage with 4 g of calibrated French large-particle talc in 13 European hospitals, and one in South Africa. The primary endpoint was the occurrence of acute respiratory distress syndrome after talc pleurodesis. Findings No patients developed acute respiratory distress syndrome (frequency 0%, one-sided 95% CI 0–0·54%). 11 (2%) patients died within 30 days. Additionally, seven patients had non-fatal post-thoracoscopy complications (1·2%), including one case of respiratory failure due to unexplained bilateral pneumothorax. Interpretation Use of large-particle talc for pleurodesis in malignant pleural effusion is safe, and not associated with the development of acute respiratory distress syndrome." @default.
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- W2157149369 date "2007-05-01" @default.
- W2157149369 modified "2023-10-18" @default.
- W2157149369 title "Safety of pleurodesis with talc poudrage in malignant pleural effusion: a prospective cohort study" @default.
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- W2157149369 doi "https://doi.org/10.1016/s0140-6736(07)60708-9" @default.
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