Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157151790> ?p ?o ?g. }
- W2157151790 endingPage "1365" @default.
- W2157151790 startingPage "1354" @default.
- W2157151790 abstract "The specific ability of the major human fungal pathogen Candida albicans, as well as many other pathogenic fungi, to extend initial short filaments (germ tubes) into elongated hyphal filaments is important for a variety of virulence-related processes. However, the molecular mechanisms that control hyphal extension have remained poorly understood for many years. We report the identification of a novel C. albicans transcriptional regulator, UME6, which is induced in response to multiple host environmental cues and is specifically important for hyphal extension. Although capable of forming germ tubes, the ume6Delta/ume6Delta mutant exhibits a clear defect in hyphal extension both in vitro and during infection in vivo and is attenuated for virulence in a mouse model of systemic candidiasis. We also show that UME6 is an important downstream component of both the RFG1-TUP1 and NRG1-TUP1 filamentous growth regulatory pathways, and we provide evidence to suggest that Nrg1 and Ume6 function together by a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions. Our results suggest that hyphal extension is controlled by a specific transcriptional regulatory mechanism and is correlated with the maintenance of high-level expression of genes in the C. albicans filamentous growth program." @default.
- W2157151790 created "2016-06-24" @default.
- W2157151790 creator A5022852723 @default.
- W2157151790 creator A5029381500 @default.
- W2157151790 creator A5030244533 @default.
- W2157151790 creator A5038869106 @default.
- W2157151790 creator A5054857197 @default.
- W2157151790 creator A5057842403 @default.
- W2157151790 creator A5080650345 @default.
- W2157151790 creator A5084772151 @default.
- W2157151790 date "2008-04-01" @default.
- W2157151790 modified "2023-10-18" @default.
- W2157151790 title "<i>UME6</i>, a Novel Filament-specific Regulator of<i>Candida albicans</i>Hyphal Extension and Virulence" @default.
- W2157151790 cites W1541663010 @default.
- W2157151790 cites W1582560245 @default.
- W2157151790 cites W1772165518 @default.
- W2157151790 cites W1832240599 @default.
- W2157151790 cites W1836455399 @default.
- W2157151790 cites W1886048289 @default.
- W2157151790 cites W1892030338 @default.
- W2157151790 cites W1893303563 @default.
- W2157151790 cites W1915890538 @default.
- W2157151790 cites W1917430189 @default.
- W2157151790 cites W1943102038 @default.
- W2157151790 cites W1965771432 @default.
- W2157151790 cites W1971159078 @default.
- W2157151790 cites W1975755124 @default.
- W2157151790 cites W1990474165 @default.
- W2157151790 cites W1999162249 @default.
- W2157151790 cites W1999340863 @default.
- W2157151790 cites W2002379595 @default.
- W2157151790 cites W2007581658 @default.
- W2157151790 cites W2010335504 @default.
- W2157151790 cites W2012034776 @default.
- W2157151790 cites W2013439407 @default.
- W2157151790 cites W2024872322 @default.
- W2157151790 cites W2027551094 @default.
- W2157151790 cites W2036686552 @default.
- W2157151790 cites W2048093614 @default.
- W2157151790 cites W2049219353 @default.
- W2157151790 cites W2053121200 @default.
- W2157151790 cites W2057750664 @default.
- W2157151790 cites W2060322845 @default.
- W2157151790 cites W2063065500 @default.
- W2157151790 cites W2067409920 @default.
- W2157151790 cites W2096580557 @default.
- W2157151790 cites W2100849490 @default.
- W2157151790 cites W2103813830 @default.
- W2157151790 cites W2106451562 @default.
- W2157151790 cites W2107734856 @default.
- W2157151790 cites W2113880496 @default.
- W2157151790 cites W2122653633 @default.
- W2157151790 cites W2123070440 @default.
- W2157151790 cites W2125605543 @default.
- W2157151790 cites W2126966227 @default.
- W2157151790 cites W2128126813 @default.
- W2157151790 cites W2128207311 @default.
- W2157151790 cites W2128413056 @default.
- W2157151790 cites W2131372853 @default.
- W2157151790 cites W2133183053 @default.
- W2157151790 cites W2134338149 @default.
- W2157151790 cites W2135707527 @default.
- W2157151790 cites W2137044047 @default.
- W2157151790 cites W2140060291 @default.
- W2157151790 cites W2140935709 @default.
- W2157151790 cites W2142140971 @default.
- W2157151790 cites W2145492995 @default.
- W2157151790 cites W2148376015 @default.
- W2157151790 cites W2150080681 @default.
- W2157151790 cites W2150938890 @default.
- W2157151790 cites W2152482111 @default.
- W2157151790 cites W2152727338 @default.
- W2157151790 cites W2153953877 @default.
- W2157151790 cites W2157766752 @default.
- W2157151790 cites W2160482993 @default.
- W2157151790 cites W2166704438 @default.
- W2157151790 cites W2171871028 @default.
- W2157151790 cites W2576734941 @default.
- W2157151790 doi "https://doi.org/10.1091/mbc.e07-11-1110" @default.
- W2157151790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2291399" @default.
- W2157151790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18216277" @default.
- W2157151790 hasPublicationYear "2008" @default.
- W2157151790 type Work @default.
- W2157151790 sameAs 2157151790 @default.
- W2157151790 citedByCount "204" @default.
- W2157151790 countsByYear W21571517902012 @default.
- W2157151790 countsByYear W21571517902013 @default.
- W2157151790 countsByYear W21571517902014 @default.
- W2157151790 countsByYear W21571517902015 @default.
- W2157151790 countsByYear W21571517902016 @default.
- W2157151790 countsByYear W21571517902017 @default.
- W2157151790 countsByYear W21571517902018 @default.
- W2157151790 countsByYear W21571517902019 @default.
- W2157151790 countsByYear W21571517902020 @default.
- W2157151790 countsByYear W21571517902021 @default.
- W2157151790 countsByYear W21571517902022 @default.
- W2157151790 countsByYear W21571517902023 @default.
- W2157151790 crossrefType "journal-article" @default.