FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157154651> ?p ?o ?g. }

• W2157154651 endingPage "533" @default.
• W2157154651 startingPage "524" @default.
• W2157154651 abstract "The immature brain has a higher susceptibility to develop seizures, which often respond poorly to classical pharmacological treatment. It has been recently suggested that bumetanide, which blocks Na+-dependent K+-Cl−-cotransporter isoform 1 (NKCC1) and thus attenuates depolarizing GABAergic responses, could soothe epileptiform activity in immature nervous systems. To evaluate whether bumetanide consistently attenuates epileptiform activity, we investigated the effect of 10 μM bumetanide in five different in-vitro epilepsy models using field potential recordings in the CA3 region of intact mouse hippocampal preparations at postnatal day 4–7. Bumetanide reduced amplitude and frequency of ictal-like events (ILE) induced by 8.5 mM K+, but it increased the frequency of ILE induced by 1 μM kainate. Inhibition of ligand-gated Cl− channels by 10 μM gabazine and 30 μM strychnine induced interictal activity (IA) that was only marginally affected by bumetanide. Removal of extracellular Mg2+ induced both ILE and IA. Bumetanide had no effect on these ILE but enhanced the IA. Low-Mg2+ solution containing 20 μM 4-AP induced late-recurrent discharges, which were slightly attenuated by bumetanide. In summary, our results demonstrate that bumetanide exerts diverse effects in different in-vitro epilepsy models." @default.
• W2157154651 created "2016-06-24" @default.
• W2157154651 creator A5035396519 @default.
• W2157154651 creator A5049609245 @default.
• W2157154651 creator A5065994712 @default.
• W2157154651 date "2007-09-01" @default.
• W2157154651 modified "2023-10-03" @default.
• W2157154651 title "Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse" @default.
• W2157154651 cites W1498226540 @default.
• W2157154651 cites W1541948668 @default.
• W2157154651 cites W1563576581 @default.
• W2157154651 cites W1856380311 @default.
• W2157154651 cites W1977260782 @default.
• W2157154651 cites W1977571678 @default.
• W2157154651 cites W1988492753 @default.
• W2157154651 cites W2013026114 @default.
• W2157154651 cites W2013719288 @default.
• W2157154651 cites W2018084293 @default.
• W2157154651 cites W2018213090 @default.
• W2157154651 cites W2023578305 @default.
• W2157154651 cites W2039987293 @default.
• W2157154651 cites W2041868953 @default.
• W2157154651 cites W2048814015 @default.
• W2157154651 cites W2054278414 @default.
• W2157154651 cites W2083658603 @default.
• W2157154651 cites W2091040471 @default.
• W2157154651 cites W2099711984 @default.
• W2157154651 cites W2120336502 @default.
• W2157154651 cites W2129934770 @default.
• W2157154651 cites W2130010217 @default.
• W2157154651 cites W2158738489 @default.
• W2157154651 cites W4236885121 @default.
• W2157154651 cites W653009 @default.
• W2157154651 doi "https://doi.org/10.1016/j.neuropharm.2007.06.015" @default.
• W2157154651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17681355" @default.
• W2157154651 hasPublicationYear "2007" @default.
• W2157154651 type Work @default.
• W2157154651 sameAs 2157154651 @default.
• W2157154651 citedByCount "86" @default.
• W2157154651 countsByYear W21571546512012 @default.
• W2157154651 countsByYear W21571546512013 @default.
• W2157154651 countsByYear W21571546512014 @default.
• W2157154651 countsByYear W21571546512015 @default.
• W2157154651 countsByYear W21571546512016 @default.
• W2157154651 countsByYear W21571546512017 @default.
• W2157154651 countsByYear W21571546512018 @default.
• W2157154651 countsByYear W21571546512019 @default.
• W2157154651 countsByYear W21571546512020 @default.
• W2157154651 countsByYear W21571546512021 @default.
• W2157154651 countsByYear W21571546512023 @default.
• W2157154651 crossrefType "journal-article" @default.
• W2157154651 hasAuthorship W2157154651A5035396519 @default.
• W2157154651 hasAuthorship W2157154651A5049609245 @default.
• W2157154651 hasAuthorship W2157154651A5065994712 @default.
• W2157154651 hasConcept C112592302 @default.
• W2157154651 hasConcept C115955781 @default.
• W2157154651 hasConcept C126322002 @default.
• W2157154651 hasConcept C134018914 @default.
• W2157154651 hasConcept C148762608 @default.
• W2157154651 hasConcept C169760540 @default.
• W2157154651 hasConcept C170493617 @default.
• W2157154651 hasConcept C178790620 @default.
• W2157154651 hasConcept C185592680 @default.
• W2157154651 hasConcept C188053792 @default.
• W2157154651 hasConcept C2775858608 @default.
• W2157154651 hasConcept C2776919887 @default.
• W2157154651 hasConcept C2777010014 @default.
• W2157154651 hasConcept C2777725853 @default.
• W2157154651 hasConcept C2778186239 @default.
• W2157154651 hasConcept C2778212192 @default.
• W2157154651 hasConcept C2781161787 @default.
• W2157154651 hasConcept C519063684 @default.
• W2157154651 hasConcept C537181965 @default.
• W2157154651 hasConcept C55493867 @default.
• W2157154651 hasConcept C67018056 @default.
• W2157154651 hasConcept C71924100 @default.
• W2157154651 hasConcept C86803240 @default.
• W2157154651 hasConcept C98274493 @default.
• W2157154651 hasConceptScore W2157154651C112592302 @default.
• W2157154651 hasConceptScore W2157154651C115955781 @default.
• W2157154651 hasConceptScore W2157154651C126322002 @default.
• W2157154651 hasConceptScore W2157154651C134018914 @default.
• W2157154651 hasConceptScore W2157154651C148762608 @default.
• W2157154651 hasConceptScore W2157154651C169760540 @default.
• W2157154651 hasConceptScore W2157154651C170493617 @default.
• W2157154651 hasConceptScore W2157154651C178790620 @default.
• W2157154651 hasConceptScore W2157154651C185592680 @default.
• W2157154651 hasConceptScore W2157154651C188053792 @default.
• W2157154651 hasConceptScore W2157154651C2775858608 @default.
• W2157154651 hasConceptScore W2157154651C2776919887 @default.
• W2157154651 hasConceptScore W2157154651C2777010014 @default.
• W2157154651 hasConceptScore W2157154651C2777725853 @default.
• W2157154651 hasConceptScore W2157154651C2778186239 @default.
• W2157154651 hasConceptScore W2157154651C2778212192 @default.
• W2157154651 hasConceptScore W2157154651C2781161787 @default.
• W2157154651 hasConceptScore W2157154651C519063684 @default.
• W2157154651 hasConceptScore W2157154651C537181965 @default.
• W2157154651 hasConceptScore W2157154651C55493867 @default.

• next