FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157157836> ?p ?o ?g. }

• W2157157836 endingPage "5074" @default.
• W2157157836 startingPage "5066" @default.
• W2157157836 abstract "Two cathepsin L proteinases, cathepsin L1 and cathepsin L2, secreted by liver flukes may be involved in tissue penetration, nutrition, and protection from immune attack. To ascertain the immunoprophylactic potential of these proteinases, and of another molecule, liver fluke hemoglobin (Hb), we performed vaccine trials in cattle. In the first vaccine trial various doses of cathepsin L1 were tested. The mean protection level obtained was 53.7%. In a second vaccine trial cathepsin L1 and Hb elicited 42.5 and 43.8% protection levels, respectively, while a combination of the two molecules induced a significantly higher level of protection (51.9%). Cathepsin L2 was not examined alone; however, vaccination of cattle with a combination of cathepsin L2 and Hb elicited the highest level of protection (72.4%). The animals that received cathepsin L1-Hb or cathepsin L2-Hb showed reduced liver damage as assessed by serum glutamic dehydrogenase and gamma-glutamyl transferase levels. Furthermore, a reduced viability was observed for fluke eggs recovered from all vaccine groups. This anti-embryonation effect of vaccination was particularly evident in the group that received cathepsin L2-Hb where >98% of the eggs recovered did not embryonate to miracidia. Although all vaccine preparations induced high antibody titers which were boosted following the challenge infection, there was no correlation between antibody titers and protection. The results of these trials demonstrate that cathepsin Ls and Hb could form the basis of a molecular vaccine that would not only reduce parasite burden but would also prevent transmission of liver fluke disease." @default.
• W2157157836 created "2016-06-24" @default.
• W2157157836 creator A5067106793 @default.
• W2157157836 creator A5068314774 @default.
• W2157157836 creator A5068367604 @default.
• W2157157836 creator A5090570108 @default.
• W2157157836 date "1996-12-01" @default.
• W2157157836 modified "2023-10-16" @default.
• W2157157836 title "Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin" @default.
• W2157157836 cites W1505509116 @default.
• W2157157836 cites W1544021266 @default.
• W2157157836 cites W1831621883 @default.
• W2157157836 cites W1920882677 @default.
• W2157157836 cites W1978451204 @default.
• W2157157836 cites W1985445149 @default.
• W2157157836 cites W2005798484 @default.
• W2157157836 cites W2008614157 @default.
• W2157157836 cites W2011885165 @default.
• W2157157836 cites W2017138031 @default.
• W2157157836 cites W2020002232 @default.
• W2157157836 cites W2020693612 @default.
• W2157157836 cites W2023147115 @default.
• W2157157836 cites W2026436981 @default.
• W2157157836 cites W2026931167 @default.
• W2157157836 cites W2049571313 @default.
• W2157157836 cites W2052416952 @default.
• W2157157836 cites W2054871510 @default.
• W2157157836 cites W2073684122 @default.
• W2157157836 cites W2077684397 @default.
• W2157157836 cites W2082906717 @default.
• W2157157836 cites W2090575725 @default.
• W2157157836 cites W2119340360 @default.
• W2157157836 cites W2131184414 @default.
• W2157157836 cites W2134179446 @default.
• W2157157836 cites W2139851406 @default.
• W2157157836 cites W2161368535 @default.
• W2157157836 cites W2163664917 @default.
• W2157157836 cites W50277004 @default.
• W2157157836 doi "https://doi.org/10.1128/iai.64.12.5066-5074.1996" @default.
• W2157157836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/174490" @default.
• W2157157836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8945548" @default.
• W2157157836 hasPublicationYear "1996" @default.
• W2157157836 type Work @default.
• W2157157836 sameAs 2157157836 @default.
• W2157157836 citedByCount "230" @default.
• W2157157836 countsByYear W21571578362012 @default.
• W2157157836 countsByYear W21571578362013 @default.
• W2157157836 countsByYear W21571578362014 @default.
• W2157157836 countsByYear W21571578362015 @default.
• W2157157836 countsByYear W21571578362016 @default.
• W2157157836 countsByYear W21571578362017 @default.
• W2157157836 countsByYear W21571578362018 @default.
• W2157157836 countsByYear W21571578362019 @default.
• W2157157836 countsByYear W21571578362020 @default.
• W2157157836 countsByYear W21571578362021 @default.
• W2157157836 countsByYear W21571578362022 @default.
• W2157157836 countsByYear W21571578362023 @default.
• W2157157836 crossrefType "journal-article" @default.
• W2157157836 hasAuthorship W2157157836A5067106793 @default.
• W2157157836 hasAuthorship W2157157836A5068314774 @default.
• W2157157836 hasAuthorship W2157157836A5068367604 @default.
• W2157157836 hasAuthorship W2157157836A5090570108 @default.
• W2157157836 hasBestOaLocation W21571578361 @default.
• W2157157836 hasConcept C159047783 @default.
• W2157157836 hasConcept C165901193 @default.
• W2157157836 hasConcept C167844969 @default.
• W2157157836 hasConcept C181199279 @default.
• W2157157836 hasConcept C203014093 @default.
• W2157157836 hasConcept C22070199 @default.
• W2157157836 hasConcept C2777856171 @default.
• W2157157836 hasConcept C2780034444 @default.
• W2157157836 hasConcept C55493867 @default.
• W2157157836 hasConcept C81216549 @default.
• W2157157836 hasConcept C86803240 @default.
• W2157157836 hasConceptScore W2157157836C159047783 @default.
• W2157157836 hasConceptScore W2157157836C165901193 @default.
• W2157157836 hasConceptScore W2157157836C167844969 @default.
• W2157157836 hasConceptScore W2157157836C181199279 @default.
• W2157157836 hasConceptScore W2157157836C203014093 @default.
• W2157157836 hasConceptScore W2157157836C22070199 @default.
• W2157157836 hasConceptScore W2157157836C2777856171 @default.
• W2157157836 hasConceptScore W2157157836C2780034444 @default.
• W2157157836 hasConceptScore W2157157836C55493867 @default.
• W2157157836 hasConceptScore W2157157836C81216549 @default.
• W2157157836 hasConceptScore W2157157836C86803240 @default.
• W2157157836 hasIssue "12" @default.
• W2157157836 hasLocation W21571578361 @default.
• W2157157836 hasLocation W21571578362 @default.
• W2157157836 hasLocation W21571578363 @default.
• W2157157836 hasOpenAccess W2157157836 @default.
• W2157157836 hasPrimaryLocation W21571578361 @default.
• W2157157836 hasRelatedWork W1974771305 @default.
• W2157157836 hasRelatedWork W1991743944 @default.
• W2157157836 hasRelatedWork W1998067923 @default.
• W2157157836 hasRelatedWork W2055619941 @default.
• W2157157836 hasRelatedWork W2086190399 @default.
• W2157157836 hasRelatedWork W2106262480 @default.
• W2157157836 hasRelatedWork W2134179446 @default.

• next