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• W2157163914 abstract "Head-up tilt (HUT) induces a reduction in preload, which is thought to be restored through sympathetic venoconstriction, reducing unstressed volume (V u ) and venous compliance (VeC). In this study, we assessed venous inflow and outflow responses and their reproducibility and determined the relation with autonomic function during HUT. Eight healthy non-pregnant women were subjected to 20° head-down tilt to 60° HUT at 20° intervals. At each rotational step, we randomly assessed forearm pressure-volume (P-V) curves (venous occlusion plethysmography) during inflow (VeC IN ) and outflow [venous emptying rate (VER OUT )]. VeC IN was defined as the ratio of the slope of the volume-time curve and pressure-time curve, with direct intravenous pressure measurement. VER OUT was determined using the derivate of a quadratic regression model using cuff pressure. We defined V u as the y-intercept of the P-V curve. We calculated, for both methods, the coefficients of reproducibility (CR) and variation (CV). Vascular sympathetic activity was determined by spectral analysis. VeC IN decreased at each rotational step compared with the supine position ( P < 0.05), whereas VER OUT increased. CR of VeC IN was higher in the supine position than VER OUT but lower during HUT. CV varied between 19% and 25% (VeC IN ) and between 12% and 21% (VER OUT ). HUT decreased V u . The change in VeC IN and VER OUT correlated with the change in vascular sympathetic activity ( r = −0.36, P < 0.01, and r = 0.48, P < 0.01). This is the first study in which a reproducible reduction in VeC IN and V u and a rise in VER OUT during HUT are documented. The alterations in venous characteristics relate to changes in vascular sympathetic activity." @default.
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• W2157163914 date "2008-10-01" @default.
• W2157163914 modified "2023-10-01" @default.
• W2157163914 title "Venous response to orthostatic stress" @default.
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• W2157163914 doi "https://doi.org/10.1152/ajpheart.00571.2008" @default.
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