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- W21571649 abstract "The extensive potential for cell proliferation and differentiation of hematopoietic stem cells is clearly demonstrated in experimental systems. The bone marrow of one mouse repopulates about 2000 potentially lethally irradiated mice. In turn, each of these mice provides cells for a similar number of second generation recipients. In turn under certain conditions these may repopulate a third generation of mice (Harrison and Astle, 1982). In recent experiments, as few as 30 highly purified putative stem cells injected into irradiated mice permanently repopulated the lymphohematopoietic tissue (Spangrude et al., 1995). With only about 20% of the injected cells expected to lodge in the bone marrow (Testa et al., 1972), it is likely that five or six of the cells injected originated all the lymphohematopoietic cells in these animals. Recently, another study demonstrated that one injected cell with a “stem cell” phenotype can reconstitute hematopoiesis in an irradiated mouse (Osawa et al., 1996). Again, the proportion of mice reconstituted after injection with a single cell agrees with the expected proportion of cells that seed in the bone marrow. Transplantation studies with marked murine cells have demonstrated that monoclonal or oligoclonal hematopoiesis occurs for long periods of time (Capel et al., 1989; Keller and Snodgrass, 1990). Only limited data are available in larger mammals. In experiments with cats a small number of syngeneic putative stem cells maintain hematopoiesis (Abkowitz et al., 1995)." @default.
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- W21571649 date "1999-01-01" @default.
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- W21571649 title "Hemopoietic Stem Cells as Targets for Genetic Manipulation" @default.
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