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- W2157183362 abstract "We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy." @default.
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- W2157183362 date "2014-05-28" @default.
- W2157183362 modified "2023-09-29" @default.
- W2157183362 title "Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging" @default.
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- W2157183362 doi "https://doi.org/10.1088/0957-4484/25/24/245103" @default.
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