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- W2157215698 abstract "L’objectif était de comparer les performances de la TEP/TDM et de la TDM pour le bilan d’extension et l’évaluation thérapeutique des tumeurs germinales séminomateuses (TGS) du testicule et d’apprécier la valeur pronostique en fin de traitement. Trente-deux patients et un maximum de 65 cibles ont été analysés et comparés en TEP/TDM et en TDM dans le cadre du bilan d’extension et de la réponse thérapeutique. Chaque lésion a été quantifiée par différentes méthodes de normalisation de standardized uptake value (SUV). Le seuil optimal de SUV pour la prédiction de la réponse thérapeutique a été calculé par analyse receiver operating characteristics (ROC). La valeur pronostique de la TEP/TDM en fin de traitement a été évaluée par étude de la survie sans récidive (Kaplan-Meier). La TEP/TDM présentait toujours une exactitude supérieure à celle de la TDM dans le bilan d’extension et l’évaluation thérapeutique, respectivement, 98 % contre 83,3 % et 95,1 % contre 75,6 %. La quantification ne permettait pas d’améliorer les performances de l’analyse visuelle. La survie sans récidive était plus élevée pour les TEP/TDM négatives en fin de traitement que pour les TEP/TDM positives (p = 0,0033). Notre étude a montré de bonnes performances de la TEP/TDM comparativement à la TDM dans le bilan d’extension et de fin de traitement des TGS. Les méthodes de quantification ne sont pas plus performantes que l’analyse visuelle. L’impact pronostique de la TEP/TDM paraît prometteur, mais nécessite d’être confirmé par des études prospectives. La TEP/TDM paraît ainsi pertinente pour la stadification et l’évaluation pronostique dans les TGS. To evaluate the value of PET/CT comparatively to CT in staging and restaging after chemotherapy of testicular seminoma, to assess quantitative methods and prognostic value of PET in post-chemotherapy residual masses. Thirty-two patients and a maximum of 65 targeted lesions visualized on PET-CT and CT performed for staging and therapeutic response assessment were analysed and compared. Each lesion was quantified according to miscellaneous SUV normalized methods. Optimal threshold of SUV for prediction of residual disease was obtained (ROC method). The prognostic value of PET/CT at the completion of treatment was determined with progression free survival study (Kaplan-Meier method). PET/CT exhibited higher accuracy than CT in the initial staging and assessment of therapeutic response, respectively 98% versus 83.3% and 95.1% versus 75.6%. Quantification, whichever method, was not more efficient than visual reading for prediction of residual disease. Progression-free survival was higher with negative than with positive PET/CT (P = 0.0033). Our work demonstrates that PET/CT exhibits better accuracy than CT in both staging and restaging at the end of treatment. Quantification methods do not improve accuracy of PET/CT for prediction of viable residual disease. The prognostic value of PET/CT appears very promising and needs to be confirmed by large prospective studies. PET/CT appears to be a relevant method of prognostic stratification of the risk of relapse in seminoma." @default.
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- W2157215698 date "2012-05-01" @default.
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- W2157215698 title "Intérêt de la TEP dans le bilan d’extension et l’évaluation de la maladie résiduelle des séminomes testiculaires : étude rétrospective" @default.
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- W2157215698 doi "https://doi.org/10.1016/j.mednuc.2012.02.173" @default.
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