FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157225192> ?p ?o ?g. }

• W2157225192 abstract "Abstract Background Cellular bioenergetics (cellular respiration and accompanying ATP synthesis) is a highly sensitive biomarker of tissue injury and may be altered following infection. The status of cellular mitochondrial O 2 consumption of the lung in pulmonary RSV infection is unknown. Methods In this study, lung fragments from RSV-infected BALB/c mice were evaluated for cellular O 2 consumption, ATP content and caspase activity. The disease was induced by intranasal inoculation with the RSV strain A2 and lung specimens were analyzed on days 2–15 after inoculation. A phosphorescence O 2 analyzer that measured dissolved O 2 concentration as a function of time was used to monitor respiration. The caspase-3 substrate analogue N -acetyl-asp-glu-val-asp-7-amino-4-methylcoumarin (Ac-DEVD-AMC) was used to monitor intracellular caspases. Results O 2 concentration declined linearly with time when measured in a sealed vial containing lung fragment and glucose as a respiratory substrate, revealing its zero-order kinetics. O 2 consumption was inhibited by cyanide, confirming the oxidation occurred in the respiratory chain. Cellular respiration increased by 1.6-fold ( p <0.010) and ATP content increased by 3-fold in the first week of RSV infection. Both parameters returned to levels found in uninfected lungs in the second week of RSV infection. Intracellular caspase activity in infected lungs was similar to uninfected lungs throughout the course of disease. Conclusions Lung tissue bioenergetics is transiently enhanced in RSV infection. This energy burst, triggered by the virus or virus-induced inflammation, is an early biomarker of the disease and may be targeted for therapy." @default.
• W2157225192 created "2016-06-24" @default.
• W2157225192 creator A5016680398 @default.
• W2157225192 creator A5021945180 @default.
• W2157225192 creator A5028539861 @default.
• W2157225192 creator A5037640842 @default.
• W2157225192 creator A5037980313 @default.
• W2157225192 creator A5039005017 @default.
• W2157225192 creator A5066589057 @default.
• W2157225192 creator A5067114391 @default.
• W2157225192 creator A5072145550 @default.
• W2157225192 creator A5083606632 @default.
• W2157225192 date "2013-01-15" @default.
• W2157225192 modified "2023-10-18" @default.
• W2157225192 title "Bioenergetics of murine lungs infected with respiratory syncytial virus" @default.
• W2157225192 cites W1749863242 @default.
• W2157225192 cites W1790007141 @default.
• W2157225192 cites W1793304642 @default.
• W2157225192 cites W1956667192 @default.
• W2157225192 cites W1977981962 @default.
• W2157225192 cites W1983311155 @default.
• W2157225192 cites W1986173845 @default.
• W2157225192 cites W1986568749 @default.
• W2157225192 cites W1988530973 @default.
• W2157225192 cites W1992145913 @default.
• W2157225192 cites W2000818889 @default.
• W2157225192 cites W2001582473 @default.
• W2157225192 cites W2005812290 @default.
• W2157225192 cites W2035856844 @default.
• W2157225192 cites W2047028523 @default.
• W2157225192 cites W2054548447 @default.
• W2157225192 cites W2058870545 @default.
• W2157225192 cites W2060398589 @default.
• W2157225192 cites W2066984712 @default.
• W2157225192 cites W2074150544 @default.
• W2157225192 cites W2096984163 @default.
• W2157225192 cites W2116973575 @default.
• W2157225192 cites W2126208826 @default.
• W2157225192 cites W2128111454 @default.
• W2157225192 cites W2128274032 @default.
• W2157225192 cites W2129851516 @default.
• W2157225192 cites W2135364357 @default.
• W2157225192 cites W2155825199 @default.
• W2157225192 cites W2162435972 @default.
• W2157225192 cites W2166860906 @default.
• W2157225192 cites W2313353429 @default.
• W2157225192 cites W2322654587 @default.
• W2157225192 doi "https://doi.org/10.1186/1743-422x-10-22" @default.
• W2157225192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3616819" @default.
• W2157225192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23320837" @default.
• W2157225192 hasPublicationYear "2013" @default.
• W2157225192 type Work @default.
• W2157225192 sameAs 2157225192 @default.
• W2157225192 citedByCount "5" @default.
• W2157225192 countsByYear W21572251922013 @default.
• W2157225192 countsByYear W21572251922014 @default.
• W2157225192 countsByYear W21572251922017 @default.
• W2157225192 countsByYear W21572251922021 @default.
• W2157225192 crossrefType "journal-article" @default.
• W2157225192 hasAuthorship W2157225192A5016680398 @default.
• W2157225192 hasAuthorship W2157225192A5021945180 @default.
• W2157225192 hasAuthorship W2157225192A5028539861 @default.
• W2157225192 hasAuthorship W2157225192A5037640842 @default.
• W2157225192 hasAuthorship W2157225192A5037980313 @default.
• W2157225192 hasAuthorship W2157225192A5039005017 @default.
• W2157225192 hasAuthorship W2157225192A5066589057 @default.
• W2157225192 hasAuthorship W2157225192A5067114391 @default.
• W2157225192 hasAuthorship W2157225192A5072145550 @default.
• W2157225192 hasAuthorship W2157225192A5083606632 @default.
• W2157225192 hasBestOaLocation W21572251921 @default.
• W2157225192 hasConcept C100206155 @default.
• W2157225192 hasConcept C105702510 @default.
• W2157225192 hasConcept C126322002 @default.
• W2157225192 hasConcept C159047783 @default.
• W2157225192 hasConcept C182215343 @default.
• W2157225192 hasConcept C2522874641 @default.
• W2157225192 hasConcept C2777714996 @default.
• W2157225192 hasConcept C2777914695 @default.
• W2157225192 hasConcept C28859421 @default.
• W2157225192 hasConcept C534529494 @default.
• W2157225192 hasConcept C55493867 @default.
• W2157225192 hasConcept C59822182 @default.
• W2157225192 hasConcept C71924100 @default.
• W2157225192 hasConcept C79879829 @default.
• W2157225192 hasConcept C86803240 @default.
• W2157225192 hasConcept C89423630 @default.
• W2157225192 hasConceptScore W2157225192C100206155 @default.
• W2157225192 hasConceptScore W2157225192C105702510 @default.
• W2157225192 hasConceptScore W2157225192C126322002 @default.
• W2157225192 hasConceptScore W2157225192C159047783 @default.
• W2157225192 hasConceptScore W2157225192C182215343 @default.
• W2157225192 hasConceptScore W2157225192C2522874641 @default.
• W2157225192 hasConceptScore W2157225192C2777714996 @default.
• W2157225192 hasConceptScore W2157225192C2777914695 @default.
• W2157225192 hasConceptScore W2157225192C28859421 @default.
• W2157225192 hasConceptScore W2157225192C534529494 @default.
• W2157225192 hasConceptScore W2157225192C55493867 @default.
• W2157225192 hasConceptScore W2157225192C59822182 @default.
• W2157225192 hasConceptScore W2157225192C71924100 @default.
• W2157225192 hasConceptScore W2157225192C79879829 @default.

• next