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- W2157236444 startingPage "64" @default.
- W2157236444 abstract "Clinical trials report that the class of drugs known as statins may be neuroprotective in Alzheimer's and Parkinson's disease, and further trials are currently underway to test whether these drugs are also beneficial in multiple sclerosis and acute stroke treatment. Since statins are well tolerated and have relatively few side effects, they may be considered as viable drugs to ameliorate neurodegenerative diseases. However, the mechanism of their neuroprotective effects is only partly understood. In this article, we review the current data on the neuroprotective effects of statins and their underlying mechanisms. In the first section, we detail the mechanisms by which statins affect cellular signalling. The primary action of statins is to inhibit cellular cholesterol synthesis. However, the cholesterol synthesis pathway also has several by-products, the non-sterol isoprenoids that are also important in cellular functioning. Furthermore, reduced cholesterol levels may deplete the cholesterol-rich membrane domains known as lipid rafts, which in turn could affect cellular signalling. In the second section, we summarize how the effects on signalling translate into general neuroprotective effects through peripheral systems. Statins improve blood-flow, reduce coagulation, modulate the immune system and reduce oxidative damage. The final section deals with the effects of statins on the central nervous system, particularly during Alzheimer's and Parkinson's disease, stroke and multiple sclerosis." @default.
- W2157236444 created "2016-06-24" @default.
- W2157236444 creator A5004204177 @default.
- W2157236444 creator A5041023599 @default.
- W2157236444 creator A5049240208 @default.
- W2157236444 creator A5063259248 @default.
- W2157236444 creator A5064422858 @default.
- W2157236444 date "2009-05-01" @default.
- W2157236444 modified "2023-10-18" @default.
- W2157236444 title "Statins: Mechanisms of neuroprotection" @default.
- W2157236444 cites W1479880028 @default.
- W2157236444 cites W1513050884 @default.
- W2157236444 cites W1537398036 @default.
- W2157236444 cites W1549969043 @default.
- W2157236444 cites W1551571847 @default.
- W2157236444 cites W1583738526 @default.
- W2157236444 cites W1585642569 @default.
- W2157236444 cites W1606372460 @default.
- W2157236444 cites W1679229316 @default.
- W2157236444 cites W1701273068 @default.
- W2157236444 cites W1831632254 @default.
- W2157236444 cites W1922625321 @default.
- W2157236444 cites W1924621182 @default.
- W2157236444 cites W1953939137 @default.
- W2157236444 cites W1965347865 @default.
- W2157236444 cites W1966857887 @default.
- W2157236444 cites W1968185522 @default.
- W2157236444 cites W1974387239 @default.
- W2157236444 cites W1974440926 @default.
- W2157236444 cites W1975454216 @default.
- W2157236444 cites W1976007067 @default.
- W2157236444 cites W1976326436 @default.
- W2157236444 cites W1976804370 @default.
- W2157236444 cites W1976897228 @default.
- W2157236444 cites W1976900147 @default.
- W2157236444 cites W1977595948 @default.
- W2157236444 cites W1980857453 @default.
- W2157236444 cites W1985031528 @default.
- W2157236444 cites W1985633670 @default.
- W2157236444 cites W1988870129 @default.
- W2157236444 cites W1991867131 @default.
- W2157236444 cites W1992125460 @default.
- W2157236444 cites W1993439431 @default.
- W2157236444 cites W1993629125 @default.
- W2157236444 cites W1993817333 @default.
- W2157236444 cites W1993838960 @default.
- W2157236444 cites W1994807176 @default.
- W2157236444 cites W2000713987 @default.
- W2157236444 cites W2000866886 @default.
- W2157236444 cites W2001082025 @default.
- W2157236444 cites W2001118602 @default.
- W2157236444 cites W2001628018 @default.
- W2157236444 cites W2001947513 @default.
- W2157236444 cites W2003753329 @default.
- W2157236444 cites W2003898971 @default.
- W2157236444 cites W2004896472 @default.
- W2157236444 cites W2005215395 @default.
- W2157236444 cites W2006028058 @default.
- W2157236444 cites W2006166262 @default.
- W2157236444 cites W2008490947 @default.
- W2157236444 cites W2009001438 @default.
- W2157236444 cites W2012650310 @default.
- W2157236444 cites W2014218783 @default.
- W2157236444 cites W2014237668 @default.
- W2157236444 cites W2015034968 @default.
- W2157236444 cites W2019731805 @default.
- W2157236444 cites W2020504510 @default.
- W2157236444 cites W2021124405 @default.
- W2157236444 cites W2021355783 @default.
- W2157236444 cites W2023316773 @default.
- W2157236444 cites W2028126743 @default.
- W2157236444 cites W2028705859 @default.
- W2157236444 cites W2032616615 @default.
- W2157236444 cites W2032842463 @default.
- W2157236444 cites W2033253411 @default.
- W2157236444 cites W2033502863 @default.
- W2157236444 cites W2033511358 @default.
- W2157236444 cites W2034038074 @default.
- W2157236444 cites W2035059839 @default.
- W2157236444 cites W2036183780 @default.
- W2157236444 cites W2039414389 @default.
- W2157236444 cites W2041806154 @default.
- W2157236444 cites W2043526429 @default.
- W2157236444 cites W2044414978 @default.
- W2157236444 cites W2044541218 @default.
- W2157236444 cites W2044806074 @default.
- W2157236444 cites W2044998971 @default.
- W2157236444 cites W2045063002 @default.
- W2157236444 cites W2045919502 @default.
- W2157236444 cites W2046227343 @default.
- W2157236444 cites W2048086967 @default.
- W2157236444 cites W2048292311 @default.
- W2157236444 cites W2049186585 @default.
- W2157236444 cites W2050990982 @default.
- W2157236444 cites W2053714231 @default.
- W2157236444 cites W2054817857 @default.
- W2157236444 cites W2055680859 @default.
- W2157236444 cites W2056530140 @default.