FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157274735> ?p ?o ?g. }

• W2157274735 abstract "Chemokines play multiple roles in the development and progression in a variety of tumors. Chemokine (C-X-C motif) ligand 7 (CXCL7) has been found associated with pro-inflammatory responses, but its role in cancer growth remains unclear. Our previous study showed that R phase tumor infiltrating lymphocytes (TILs) produced large amounts of interleukin (IL)-6 which antagonized transforming growth factor (TGF)-β derived from CTVT to diminish the immune-suppressive microenvironment. Now we intend to determine the expression pattern of CXCL7 and the role of IL-6/TGF-β in CXCL7 induction during spontaneous progressive (P) and regressive (R) phases in canine transmissible venereal tumor (CTVT).We have demonstrated that CXCL7 expressed at high level in P phase and down-regulated in R phase by western blot and real-time PCR. This suggested that CXCL7 expression was negatively correlated with the tumor growth. Co-culturing TILs with CTVT cells was found to reduce CXCL7 expression, while adding IL-6 blocking antibody reversed it. Moreover, in P phase CTVT, while IL-1β and TGF-β had no obvious effect on CXCL7 expression, IL-6 was found significantly to reduce CXCL7 expression in a dose-dependent manner. The mRNA expression results of CXCL7 receptor, CXCR2, further confirmed the effects of IL-6 concentration on the CXCL7 expression.CXCL7 overexpression might be associated with the progressive growth of CTVT. The results shown here also suggest the role of CXCL7 in cancer development and the potential as the anti-cancer therapeutic target." @default.
• W2157274735 created "2016-06-24" @default.
• W2157274735 creator A5015069277 @default.
• W2157274735 creator A5030302953 @default.
• W2157274735 creator A5047446019 @default.
• W2157274735 creator A5066153564 @default.
• W2157274735 creator A5071909380 @default.
• W2157274735 creator A5079567080 @default.
• W2157274735 date "2012-11-09" @default.
• W2157274735 modified "2023-09-24" @default.
• W2157274735 title "Overexpression of chemokine ligand 7 is associated with the progression of canine transmissible venereal tumor" @default.
• W2157274735 cites W1504116691 @default.
• W2157274735 cites W1518549789 @default.
• W2157274735 cites W1568169604 @default.
• W2157274735 cites W1764421709 @default.
• W2157274735 cites W1917885463 @default.
• W2157274735 cites W1918081901 @default.
• W2157274735 cites W1955115189 @default.
• W2157274735 cites W1965639822 @default.
• W2157274735 cites W1974486772 @default.
• W2157274735 cites W1978172024 @default.
• W2157274735 cites W1999903411 @default.
• W2157274735 cites W2029599962 @default.
• W2157274735 cites W2032243094 @default.
• W2157274735 cites W2036391747 @default.
• W2157274735 cites W2037834427 @default.
• W2157274735 cites W2051810280 @default.
• W2157274735 cites W2056088187 @default.
• W2157274735 cites W2057781412 @default.
• W2157274735 cites W2066466662 @default.
• W2157274735 cites W2067773598 @default.
• W2157274735 cites W2071299302 @default.
• W2157274735 cites W2074905595 @default.
• W2157274735 cites W2077399951 @default.
• W2157274735 cites W2085264314 @default.
• W2157274735 cites W2090488685 @default.
• W2157274735 cites W2107277218 @default.
• W2157274735 cites W2122456112 @default.
• W2157274735 cites W2127760302 @default.
• W2157274735 cites W2152108405 @default.
• W2157274735 cites W2154229564 @default.
• W2157274735 cites W2156057520 @default.
• W2157274735 cites W2163873875 @default.
• W2157274735 cites W2281249544 @default.
• W2157274735 doi "https://doi.org/10.1186/1746-6148-8-216" @default.
• W2157274735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538668" @default.
• W2157274735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23136963" @default.
• W2157274735 hasPublicationYear "2012" @default.
• W2157274735 type Work @default.
• W2157274735 sameAs 2157274735 @default.
• W2157274735 citedByCount "16" @default.
• W2157274735 countsByYear W21572747352014 @default.
• W2157274735 countsByYear W21572747352015 @default.
• W2157274735 countsByYear W21572747352016 @default.
• W2157274735 countsByYear W21572747352017 @default.
• W2157274735 countsByYear W21572747352019 @default.
• W2157274735 countsByYear W21572747352020 @default.
• W2157274735 countsByYear W21572747352021 @default.
• W2157274735 countsByYear W21572747352022 @default.
• W2157274735 countsByYear W21572747352023 @default.
• W2157274735 crossrefType "journal-article" @default.
• W2157274735 hasAuthorship W2157274735A5015069277 @default.
• W2157274735 hasAuthorship W2157274735A5030302953 @default.
• W2157274735 hasAuthorship W2157274735A5047446019 @default.
• W2157274735 hasAuthorship W2157274735A5066153564 @default.
• W2157274735 hasAuthorship W2157274735A5071909380 @default.
• W2157274735 hasAuthorship W2157274735A5079567080 @default.
• W2157274735 hasBestOaLocation W21572747351 @default.
• W2157274735 hasConcept C118131993 @default.
• W2157274735 hasConcept C12823836 @default.
• W2157274735 hasConcept C13373296 @default.
• W2157274735 hasConcept C134018914 @default.
• W2157274735 hasConcept C203014093 @default.
• W2157274735 hasConcept C2776107976 @default.
• W2157274735 hasConcept C2777701055 @default.
• W2157274735 hasConcept C2778326572 @default.
• W2157274735 hasConcept C502942594 @default.
• W2157274735 hasConcept C84913492 @default.
• W2157274735 hasConcept C86803240 @default.
• W2157274735 hasConcept C8891405 @default.
• W2157274735 hasConceptScore W2157274735C118131993 @default.
• W2157274735 hasConceptScore W2157274735C12823836 @default.
• W2157274735 hasConceptScore W2157274735C13373296 @default.
• W2157274735 hasConceptScore W2157274735C134018914 @default.
• W2157274735 hasConceptScore W2157274735C203014093 @default.
• W2157274735 hasConceptScore W2157274735C2776107976 @default.
• W2157274735 hasConceptScore W2157274735C2777701055 @default.
• W2157274735 hasConceptScore W2157274735C2778326572 @default.
• W2157274735 hasConceptScore W2157274735C502942594 @default.
• W2157274735 hasConceptScore W2157274735C84913492 @default.
• W2157274735 hasConceptScore W2157274735C86803240 @default.
• W2157274735 hasConceptScore W2157274735C8891405 @default.
• W2157274735 hasIssue "1" @default.
• W2157274735 hasLocation W21572747351 @default.
• W2157274735 hasLocation W21572747352 @default.
• W2157274735 hasLocation W21572747353 @default.
• W2157274735 hasLocation W21572747354 @default.
• W2157274735 hasOpenAccess W2157274735 @default.
• W2157274735 hasPrimaryLocation W21572747351 @default.
• W2157274735 hasRelatedWork W2005666125 @default.

• next