FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157316107> ?p ?o ?g. }

• W2157316107 endingPage "148" @default.
• W2157316107 startingPage "127" @default.
• W2157316107 abstract "The view that the inner membrane possesses a structurally independent protein import system has been substantiated by the recent identification of three mitochondrial inner membrane proteins, which are essential components of the transport machinery. This chapter focuses on the properties of these translocase of the mitochondrial inner membrane (Tim)-proteins. The identification of the Tim-proteins now opens a broad area for characterization of the import apparatus. This will include the topology of the Tims, their mode of interaction with preproteins, and the specificity of the transport machinery. Of particular importance will be the analysis of the interaction of the Tims with each other and with mt-Hsp70 and partner proteins, as well as the identification of putative further components required for inner membrane transport. The process of mitochondrial protein uptake appears to be unidirectional and irreversible, that is, an imported protein is unable to move back into the cytosol. The conformational changes accompanying the import, folding, and assembly of proteins are by themselves usually not sufficient to drive an unidirectional transport. This is particularly obvious in the case ofprotein translocation across the mitochondrial inner membrane. The supply of two external energy sources, ATP and the membrane potential AY across the inner membrane, is needed to drive protein import. The chapter discusses that with some preproteins short segments may move back across the inner membrane when the function of the matrix Hsp70 is strongly impaired—for example, by ATP-depletion of the matrix, supporting the view of an energy-driven unidirectional transport." @default.
• W2157316107 created "2016-06-24" @default.
• W2157316107 creator A5014217628 @default.
• W2157316107 creator A5025108674 @default.
• W2157316107 creator A5062749637 @default.
• W2157316107 creator A5065544828 @default.
• W2157316107 date "1996-01-01" @default.
• W2157316107 modified "2023-09-25" @default.
• W2157316107 title "Translocation of Preproteins Across the Mitochondrial Inner Membrane: Tims and HSP70" @default.
• W2157316107 cites W119688228 @default.
• W2157316107 cites W1497875229 @default.
• W2157316107 cites W1504997501 @default.
• W2157316107 cites W1507617904 @default.
• W2157316107 cites W1544918831 @default.
• W2157316107 cites W1547716489 @default.
• W2157316107 cites W1588568344 @default.
• W2157316107 cites W1591848571 @default.
• W2157316107 cites W1592645568 @default.
• W2157316107 cites W1666933792 @default.
• W2157316107 cites W1672805100 @default.
• W2157316107 cites W1689925871 @default.
• W2157316107 cites W1717988203 @default.
• W2157316107 cites W1752944627 @default.
• W2157316107 cites W1764768847 @default.
• W2157316107 cites W1791589681 @default.
• W2157316107 cites W1806909533 @default.
• W2157316107 cites W1873754044 @default.
• W2157316107 cites W1964651523 @default.
• W2157316107 cites W1965129356 @default.
• W2157316107 cites W1966813371 @default.
• W2157316107 cites W1969487425 @default.
• W2157316107 cites W1976751700 @default.
• W2157316107 cites W1981188702 @default.
• W2157316107 cites W1983790844 @default.
• W2157316107 cites W1984188958 @default.
• W2157316107 cites W1989660181 @default.
• W2157316107 cites W1989789175 @default.
• W2157316107 cites W1992271142 @default.
• W2157316107 cites W1994616607 @default.
• W2157316107 cites W1999666351 @default.
• W2157316107 cites W2009502549 @default.
• W2157316107 cites W2023953172 @default.
• W2157316107 cites W2026657320 @default.
• W2157316107 cites W2028353727 @default.
• W2157316107 cites W2029075877 @default.
• W2157316107 cites W2034176931 @default.
• W2157316107 cites W2037464535 @default.
• W2157316107 cites W2039183968 @default.
• W2157316107 cites W2041579704 @default.
• W2157316107 cites W2043392684 @default.
• W2157316107 cites W204545715 @default.
• W2157316107 cites W2046929906 @default.
• W2157316107 cites W2050741966 @default.
• W2157316107 cites W2051643639 @default.
• W2157316107 cites W2062775685 @default.
• W2157316107 cites W2069490007 @default.
• W2157316107 cites W2072744250 @default.
• W2157316107 cites W2073075045 @default.
• W2157316107 cites W2074312777 @default.
• W2157316107 cites W2080195140 @default.
• W2157316107 cites W2081422975 @default.
• W2157316107 cites W2081583826 @default.
• W2157316107 cites W2085058894 @default.
• W2157316107 cites W2085604409 @default.
• W2157316107 cites W2099445270 @default.
• W2157316107 cites W2099709872 @default.
• W2157316107 cites W2101749166 @default.
• W2157316107 cites W2102355342 @default.
• W2157316107 cites W2120418365 @default.
• W2157316107 cites W2121142142 @default.
• W2157316107 cites W2121484072 @default.
• W2157316107 cites W2129398678 @default.
• W2157316107 cites W2140998993 @default.
• W2157316107 cites W2143006558 @default.
• W2157316107 cites W2151195732 @default.
• W2157316107 cites W2152214802 @default.
• W2157316107 cites W2162130926 @default.
• W2157316107 cites W2164248572 @default.
• W2157316107 cites W2166153628 @default.
• W2157316107 cites W2169035012 @default.
• W2157316107 cites W2180902922 @default.
• W2157316107 cites W2396027854 @default.
• W2157316107 cites W24469765 @default.
• W2157316107 cites W257662363 @default.
• W2157316107 cites W2688325281 @default.
• W2157316107 cites W335703571 @default.
• W2157316107 cites W4237081453 @default.
• W2157316107 cites W4242755118 @default.
• W2157316107 cites W4247255621 @default.
• W2157316107 cites W4256285583 @default.
• W2157316107 cites W62747462 @default.
• W2157316107 doi "https://doi.org/10.1016/s1569-2558(09)60012-6" @default.
• W2157316107 hasPublicationYear "1996" @default.
• W2157316107 type Work @default.
• W2157316107 sameAs 2157316107 @default.
• W2157316107 citedByCount "3" @default.
• W2157316107 crossrefType "book-chapter" @default.
• W2157316107 hasAuthorship W2157316107A5014217628 @default.

• next