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• W2157364615 endingPage "2512" @default.
• W2157364615 startingPage "2509" @default.
• W2157364615 abstract "ABSTRACT We describe a simple multiplex allele-specific (MAS)-PCR assay to detect mutations in the second base of the katG gene codon 315, including AGC→ACC and ACA (Ser→Thr) substitutions that confer resistance to isoniazid (INH) in Mycobacterium tuberculosis clinical isolates. The 315 ACC allele is found in the majority of Inh r strains worldwide, especially in areas with a high incidence of tuberculosis. The 315 ACA allele is characteristic of the New York City multidrug-resistant (MDR) strain W and its progenies in the United States. The mutations in katG315 are revealed depending on the presence or absence of an indicative fragment amplified from the wild-type allele of this codon. Initially optimized on the purified DNA samples, the assay was then tested on crude cell lysates and auramine-stained sputum slide preparations with the same reproducibility and interpretability of profiles generated by agarose gel electrophoresis. The MAS-PCR assay can be used for the detection of resistance to INH in clinical laboratories in regions with a high prevalence of MDR M. tuberculosis strains." @default.
• W2157364615 created "2016-06-24" @default.
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• W2157364615 date "2002-07-01" @default.
• W2157364615 modified "2023-09-23" @default.
• W2157364615 title "Detection of Isoniazid-Resistant <i>Mycobacterium tuberculosis</i> Strains by a Multiplex Allele-Specific PCR Assay Targeting <i>katG</i> Codon 315 Variation" @default.
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• W2157364615 doi "https://doi.org/10.1128/jcm.40.7.2509-2512.2002" @default.
• W2157364615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/120554" @default.
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