Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157393381> ?p ?o ?g. }
- W2157393381 endingPage "333" @default.
- W2157393381 startingPage "321" @default.
- W2157393381 abstract "Atherosclerosis is the main pathophysiological process underlying acute cardiovascular diseases. Life-threatening conditions, such as myocardial infarction and ischemic stroke, are provoked by the sudden rupture of vulnerable atherosclerotic plaques, characterized by thin, highly inflamed and collagen-poor fibrous cap. Whereas both innate and adaptive inflammation progressively emerged as driving force of this processes, less is known about the involvement of neutrophils (PMNs). Advances in laboratory techniques during the last two decades disclosed that PMNs play a crucial role in promoting plaque vulnerability by the release of different enzymes, such as gelatinases (matrix metalloproteinases) collagenases, elastase and myeloperoxidase. Accordingly, circulating levels of PMNs and their products have been investigated as potential markers of plaque instability in both primary and secondary prevention on cardiovascular diseases. In addition, the development of different classes of drugs targeting PMNs activation is emerging as an interesting field of research. This narrative review will provide an update on the role of PMNs in promoting plaque vulnerability also discussing the potential effects of therapeutic strategies targeting PMN on plaque vulnerability. Keywords: Atherosclerosis, inflammation, matrix metalloproteinase, myeloperoxidase, neutrophil, vulnerable plaque." @default.
- W2157393381 created "2016-06-24" @default.
- W2157393381 creator A5024812334 @default.
- W2157393381 creator A5066955897 @default.
- W2157393381 creator A5085573148 @default.
- W2157393381 date "2015-04-06" @default.
- W2157393381 modified "2023-10-16" @default.
- W2157393381 title "Update on the Role of Neutrophils in Atherosclerotic Plaque Vulnerability" @default.
- W2157393381 cites W147797962 @default.
- W2157393381 cites W1481571357 @default.
- W2157393381 cites W1484628070 @default.
- W2157393381 cites W1515001810 @default.
- W2157393381 cites W1549645780 @default.
- W2157393381 cites W1934265510 @default.
- W2157393381 cites W1956895037 @default.
- W2157393381 cites W1964448557 @default.
- W2157393381 cites W1967206176 @default.
- W2157393381 cites W1967555281 @default.
- W2157393381 cites W1967816704 @default.
- W2157393381 cites W1971924360 @default.
- W2157393381 cites W1973087845 @default.
- W2157393381 cites W1977715231 @default.
- W2157393381 cites W1977909636 @default.
- W2157393381 cites W1979829829 @default.
- W2157393381 cites W1982584793 @default.
- W2157393381 cites W1984427503 @default.
- W2157393381 cites W1990847169 @default.
- W2157393381 cites W1994868032 @default.
- W2157393381 cites W1998228301 @default.
- W2157393381 cites W1999426108 @default.
- W2157393381 cites W2000588886 @default.
- W2157393381 cites W2000974608 @default.
- W2157393381 cites W2001772900 @default.
- W2157393381 cites W2003517508 @default.
- W2157393381 cites W2003870338 @default.
- W2157393381 cites W2005955842 @default.
- W2157393381 cites W2007793689 @default.
- W2157393381 cites W2007988394 @default.
- W2157393381 cites W2009272872 @default.
- W2157393381 cites W2010978967 @default.
- W2157393381 cites W2013204959 @default.
- W2157393381 cites W2013934583 @default.
- W2157393381 cites W2016327540 @default.
- W2157393381 cites W2018860370 @default.
- W2157393381 cites W2018905179 @default.
- W2157393381 cites W2019431157 @default.
- W2157393381 cites W2019737623 @default.
- W2157393381 cites W2020452002 @default.
- W2157393381 cites W2020982843 @default.
- W2157393381 cites W2022445134 @default.
- W2157393381 cites W2024152628 @default.
- W2157393381 cites W2028257547 @default.
- W2157393381 cites W2029040680 @default.
- W2157393381 cites W2029428504 @default.
- W2157393381 cites W2031048286 @default.
- W2157393381 cites W2032598000 @default.
- W2157393381 cites W2043769111 @default.
- W2157393381 cites W2044477396 @default.
- W2157393381 cites W2045317267 @default.
- W2157393381 cites W2045870074 @default.
- W2157393381 cites W2046721689 @default.
- W2157393381 cites W2047489942 @default.
- W2157393381 cites W2047637451 @default.
- W2157393381 cites W2047916461 @default.
- W2157393381 cites W2048801137 @default.
- W2157393381 cites W2053658327 @default.
- W2157393381 cites W2054753294 @default.
- W2157393381 cites W2055223329 @default.
- W2157393381 cites W2055994934 @default.
- W2157393381 cites W2056117234 @default.
- W2157393381 cites W2056993290 @default.
- W2157393381 cites W2057383481 @default.
- W2157393381 cites W2058467062 @default.
- W2157393381 cites W2058995899 @default.
- W2157393381 cites W2059509755 @default.
- W2157393381 cites W2059532851 @default.
- W2157393381 cites W2061367553 @default.
- W2157393381 cites W2064175857 @default.
- W2157393381 cites W2065302244 @default.
- W2157393381 cites W2065432525 @default.
- W2157393381 cites W2066963386 @default.
- W2157393381 cites W2067066721 @default.
- W2157393381 cites W2068992138 @default.
- W2157393381 cites W2071006637 @default.
- W2157393381 cites W2071651599 @default.
- W2157393381 cites W2071978209 @default.
- W2157393381 cites W2074897979 @default.
- W2157393381 cites W2076420076 @default.
- W2157393381 cites W2076462546 @default.
- W2157393381 cites W2079486986 @default.
- W2157393381 cites W2081344100 @default.
- W2157393381 cites W2081502526 @default.
- W2157393381 cites W2085525890 @default.
- W2157393381 cites W2086564359 @default.
- W2157393381 cites W2087314212 @default.
- W2157393381 cites W2088023626 @default.
- W2157393381 cites W2088728082 @default.
- W2157393381 cites W2089020491 @default.