FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157404700> ?p ?o ?g. }

• W2157404700 endingPage "1399" @default.
• W2157404700 startingPage "1396" @default.
• W2157404700 abstract "HDL has anti-atherogenic properties, and plasma levels of HDL cholesterol correlate inversely with risk of coronary artery disease. HDL reportedly functions as a cofactor to the anticoagulant activated protein C (APC) in the degradation of factor Va (FVa). The aim of the present study was to elucidate the mechanism by which HDL functions as cofactor to APC. Consistent with a previous report, HDL isolated from human plasma by ultracentrifugation was found to stimulate APC-mediated degradation of FVa. However, further purification of HDL by gel filtration revealed that the stimulating activity was not a property of HDL. Instead, the stimulating activity eluted completely separately from HDL in the high-molecular-weight void volume fractions. The active portion of these fractions stimulated FVa degradation by APC and supported the assembly of factor Xa and FVa into a functional prothrombinase complex. Both the procoagulant and anticoagulant activities were blocked by addition of annexin V, suggesting that the active portion was negatively charged phospholipid membranes. These results demonstrate that HDL does not stimulate the APC/protein S effect and that the activity previously reported to be a property of HDL is instead caused by contaminating negatively charged phospholipid membranes." @default.
• W2157404700 created "2016-06-24" @default.
• W2157404700 creator A5009459466 @default.
• W2157404700 creator A5038235735 @default.
• W2157404700 creator A5065826476 @default.
• W2157404700 date "2010-05-03" @default.
• W2157404700 modified "2023-10-15" @default.
• W2157404700 title "Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans" @default.
• W2157404700 cites W1490172408 @default.
• W2157404700 cites W1578912075 @default.
• W2157404700 cites W1580145878 @default.
• W2157404700 cites W1584149880 @default.
• W2157404700 cites W1981357038 @default.
• W2157404700 cites W1998505413 @default.
• W2157404700 cites W1999196234 @default.
• W2157404700 cites W2005574282 @default.
• W2157404700 cites W2009287427 @default.
• W2157404700 cites W2019858560 @default.
• W2157404700 cites W2025155898 @default.
• W2157404700 cites W2063868052 @default.
• W2157404700 cites W2069898248 @default.
• W2157404700 cites W2077760013 @default.
• W2157404700 cites W2081366175 @default.
• W2157404700 cites W2088677753 @default.
• W2157404700 cites W2094768566 @default.
• W2157404700 cites W2098076038 @default.
• W2157404700 cites W2104431307 @default.
• W2157404700 cites W2116409842 @default.
• W2157404700 cites W2117510612 @default.
• W2157404700 cites W2135806933 @default.
• W2157404700 cites W2162949693 @default.
• W2157404700 cites W2167488666 @default.
• W2157404700 cites W2405792071 @default.
• W2157404700 cites W2414143925 @default.
• W2157404700 cites W4253436283 @default.
• W2157404700 doi "https://doi.org/10.1172/jci42260" @default.
• W2157404700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860911" @default.
• W2157404700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20446351" @default.
• W2157404700 hasPublicationYear "2010" @default.
• W2157404700 type Work @default.
• W2157404700 sameAs 2157404700 @default.
• W2157404700 citedByCount "14" @default.
• W2157404700 countsByYear W21574047002012 @default.
• W2157404700 countsByYear W21574047002013 @default.
• W2157404700 countsByYear W21574047002014 @default.
• W2157404700 countsByYear W21574047002015 @default.
• W2157404700 countsByYear W21574047002016 @default.
• W2157404700 countsByYear W21574047002020 @default.
• W2157404700 countsByYear W21574047002022 @default.
• W2157404700 countsByYear W21574047002023 @default.
• W2157404700 crossrefType "journal-article" @default.
• W2157404700 hasAuthorship W2157404700A5009459466 @default.
• W2157404700 hasAuthorship W2157404700A5038235735 @default.
• W2157404700 hasAuthorship W2157404700A5065826476 @default.
• W2157404700 hasBestOaLocation W21574047001 @default.
• W2157404700 hasConcept C112516734 @default.
• W2157404700 hasConcept C126322002 @default.
• W2157404700 hasConcept C134018914 @default.
• W2157404700 hasConcept C144594695 @default.
• W2157404700 hasConcept C185592680 @default.
• W2157404700 hasConcept C2776135265 @default.
• W2157404700 hasConcept C2777292125 @default.
• W2157404700 hasConcept C2778163477 @default.
• W2157404700 hasConcept C2778382381 @default.
• W2157404700 hasConcept C2778918659 @default.
• W2157404700 hasConcept C2779637612 @default.
• W2157404700 hasConcept C2780072125 @default.
• W2157404700 hasConcept C2781287897 @default.
• W2157404700 hasConcept C41625074 @default.
• W2157404700 hasConcept C54689828 @default.
• W2157404700 hasConcept C55493867 @default.
• W2157404700 hasConcept C71924100 @default.
• W2157404700 hasConcept C86803240 @default.
• W2157404700 hasConcept C89560881 @default.
• W2157404700 hasConceptScore W2157404700C112516734 @default.
• W2157404700 hasConceptScore W2157404700C126322002 @default.
• W2157404700 hasConceptScore W2157404700C134018914 @default.
• W2157404700 hasConceptScore W2157404700C144594695 @default.
• W2157404700 hasConceptScore W2157404700C185592680 @default.
• W2157404700 hasConceptScore W2157404700C2776135265 @default.
• W2157404700 hasConceptScore W2157404700C2777292125 @default.
• W2157404700 hasConceptScore W2157404700C2778163477 @default.
• W2157404700 hasConceptScore W2157404700C2778382381 @default.
• W2157404700 hasConceptScore W2157404700C2778918659 @default.
• W2157404700 hasConceptScore W2157404700C2779637612 @default.
• W2157404700 hasConceptScore W2157404700C2780072125 @default.
• W2157404700 hasConceptScore W2157404700C2781287897 @default.
• W2157404700 hasConceptScore W2157404700C41625074 @default.
• W2157404700 hasConceptScore W2157404700C54689828 @default.
• W2157404700 hasConceptScore W2157404700C55493867 @default.
• W2157404700 hasConceptScore W2157404700C71924100 @default.
• W2157404700 hasConceptScore W2157404700C86803240 @default.
• W2157404700 hasConceptScore W2157404700C89560881 @default.
• W2157404700 hasIssue "5" @default.
• W2157404700 hasLocation W21574047001 @default.
• W2157404700 hasLocation W21574047002 @default.
• W2157404700 hasLocation W21574047003 @default.
• W2157404700 hasLocation W21574047004 @default.

• next