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- W2157473974 abstract "Abstract The use of tributyltin (TBT) as a biocide in antifouling paints leads to a ruinous input of this contaminant in the aquatic environment. Human exposure to TBT mainly occurs through ingestion of contaminated seafood such as filter‐feeding mollusks. Tributyltin is known to act as a membrane‐active toxicant on several targets, but especially on the mitochondria, and by several mechanisms. The effects of tributyltin on fatty acid composition, on Mg‐adenosine triphosphatase (ATPase) activities, and on the membrane physical state were investigated in gill mitochondrial membranes from cultivated mussels Mytilus galloprovincialis exposed to 0.5 µg/L and 1.0 µg/L TBT and unexposed for 120 h. The higher TBT exposure dose induced a decrease in the total and n‐3 polyunsaturated fatty acids (PUFAs), especially 22:6 n‐3, and an activation of the oligomycin‐sensitive Mg‐ATPase. Both TBT concentrations decreased mitochondrial membrane polarity detected by Laurdan steady‐state fluorescence spectroscopy. These findings may help cast light on the multiple modes of action of this toxicant. Environ. Toxicol. Chem. 2012;31:877–884. © 2012 SETAC" @default.
- W2157473974 created "2016-06-24" @default.
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- W2157473974 date "2012-02-28" @default.
- W2157473974 modified "2023-10-16" @default.
- W2157473974 title "Structural and functional changes in gill mitochondrial membranes from the Mediterranean mussel Mytilus galloprovincialis exposed to tri-n-butyltin" @default.
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- W2157473974 doi "https://doi.org/10.1002/etc.1764" @default.
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