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- W2157515809 abstract "Nitric oxide (.NO) and its reactive derivative peroxynitrite (ONOO 7 ) have been implicated in the pathogenesis of multiple sclerosis (MS). They are cytotoxic to oligodendrocytes and neurones in culture by inhibiting the mitochondrial respiratory chain (complexes II/III and IV) and inhibiting certain key intracellular enzymes. Recently .NO has been implicated as a possible aetiological factor in reversible conduction block in demyelinated axons. Inducible nitric oxide synthase (iNOS) is upregulated in the central nervous system of animals with experimental allergic encephalomyelitis (EAE) and in patients with MS. In some EAE models inhibiting iNOS activity decreases disease severity whilst in other models disease activity is exacerbated. Raised levels of nitrate and nitrite, stable end-products of .NO/ONOO 7 , are found in the cerebrospinal fluid, serum and urine of patients with MS. CSF levels of nitrate and nitrite correlate with blood-brain-barrier dysfunction, which suggests that .NO may play a role in inflammatory blood-brain-barrier dysfunction. In a longitudinal study on 24 patients with relapsing remitting and secondary progressive MS, raised serum nitrate and nitrite levels correlated with a relapsing course and infrequent relapses. However, no correlation was found between raised serum levels of nitrate and nitrite and MRI activity, disease progression, or the development of cerebral atrophy. In autoimmune mediated CNS demyelinating disease .NO may be a double-edged sword, mediating tissue damage on the one hand and on the other hand modulating complex immunological functions which may be protective." @default.
- W2157515809 created "2016-06-24" @default.
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- W2157515809 date "1998-06-01" @default.
- W2157515809 modified "2023-10-18" @default.
- W2157515809 title "The potential role of nitric oxide in multiple sclerosis" @default.
- W2157515809 cites W1481797092 @default.
- W2157515809 cites W1496457337 @default.
- W2157515809 cites W1509127316 @default.
- W2157515809 cites W1950460235 @default.
- W2157515809 cites W1964634019 @default.
- W2157515809 cites W1969097342 @default.
- W2157515809 cites W1971335269 @default.
- W2157515809 cites W1979312185 @default.
- W2157515809 cites W1982030010 @default.
- W2157515809 cites W1982084620 @default.
- W2157515809 cites W1987753834 @default.
- W2157515809 cites W1989639366 @default.
- W2157515809 cites W1990581744 @default.
- W2157515809 cites W1991000309 @default.
- W2157515809 cites W1995651325 @default.
- W2157515809 cites W1999053928 @default.
- W2157515809 cites W2002273797 @default.
- W2157515809 cites W2003404259 @default.
- W2157515809 cites W2006048914 @default.
- W2157515809 cites W2010694257 @default.
- W2157515809 cites W2011056756 @default.
- W2157515809 cites W2011730327 @default.
- W2157515809 cites W2011769338 @default.
- W2157515809 cites W2012536557 @default.
- W2157515809 cites W2012747120 @default.
- W2157515809 cites W2014797476 @default.
- W2157515809 cites W2018205667 @default.
- W2157515809 cites W2020644019 @default.
- W2157515809 cites W2021466428 @default.
- W2157515809 cites W2021533801 @default.
- W2157515809 cites W2022473067 @default.
- W2157515809 cites W2030356017 @default.
- W2157515809 cites W2031039608 @default.
- W2157515809 cites W2031925670 @default.
- W2157515809 cites W2035546426 @default.
- W2157515809 cites W2036787165 @default.
- W2157515809 cites W2039674246 @default.
- W2157515809 cites W2042632237 @default.
- W2157515809 cites W2046508329 @default.
- W2157515809 cites W2049453495 @default.
- W2157515809 cites W2051329971 @default.
- W2157515809 cites W2051890182 @default.
- W2157515809 cites W2053813372 @default.
- W2157515809 cites W2058137293 @default.
- W2157515809 cites W2061747759 @default.
- W2157515809 cites W2063388001 @default.
- W2157515809 cites W2065083920 @default.
- W2157515809 cites W2065287046 @default.
- W2157515809 cites W2067053609 @default.
- W2157515809 cites W2079612621 @default.
- W2157515809 cites W2079982783 @default.
- W2157515809 cites W2080557682 @default.
- W2157515809 cites W2104841128 @default.
- W2157515809 cites W2106554511 @default.
- W2157515809 cites W2109825003 @default.
- W2157515809 cites W2113279573 @default.
- W2157515809 cites W2113580903 @default.
- W2157515809 cites W2122644897 @default.
- W2157515809 cites W2125110523 @default.
- W2157515809 cites W2126244626 @default.
- W2157515809 cites W2129250847 @default.
- W2157515809 cites W2130040827 @default.
- W2157515809 cites W2139367012 @default.
- W2157515809 cites W2151735361 @default.
- W2157515809 cites W2152098493 @default.
- W2157515809 cites W2313326603 @default.
- W2157515809 cites W2400403112 @default.
- W2157515809 cites W2415073687 @default.
- W2157515809 cites W4210548604 @default.
- W2157515809 doi "https://doi.org/10.1177/135245859800400323" @default.
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