Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157525101> ?p ?o ?g. }
- W2157525101 endingPage "610" @default.
- W2157525101 startingPage "602" @default.
- W2157525101 abstract "Currently, no suitable biomarkers for the early detection of pancreatic cancer (PC) are available. Proteins present in the serum could reflect a state of the disease. In this study, these profiles as a diagnostic marker for PC were evaluated.Serum samples were obtained from PC patients (n = 50 calibration set, n = 39 validation set) and healthy volunteers (n = 110 and n = 75 respectively) according to a uniform standardized collection and processing protocol. For peptide and protein isolation, automated solid-phase extraction (SPE) with Weak Cation Exchange (WCX) magnetic beads (MB) was performed using a 96-channel liquid handling platform. Protein profiles were obtained by mass spectrometry (MS) and evaluated by linear discriminant analysis with double cross-validation.A discriminating profile for PC has been identified, with a sensitivity of 78% and a specificity of 89% in the calibration set with an area under the curve (AUC) of 90%. These results were validated with a sensitivity of 74% and a specificity of 91% (AUC 90%).Serum profiles of healthy controls and PC can be discrimated between. Further research is warranted to evaluate specificity and whether this biosignature can be used for early detection in a high risk population." @default.
- W2157525101 created "2016-06-24" @default.
- W2157525101 creator A5002727500 @default.
- W2157525101 creator A5010756339 @default.
- W2157525101 creator A5031930566 @default.
- W2157525101 creator A5039947825 @default.
- W2157525101 creator A5049672570 @default.
- W2157525101 creator A5052876669 @default.
- W2157525101 creator A5081893214 @default.
- W2157525101 creator A5084721292 @default.
- W2157525101 creator A5084788672 @default.
- W2157525101 date "2013-08-01" @default.
- W2157525101 modified "2023-10-18" @default.
- W2157525101 title "Detection of pancreatic cancer using serum protein profiling" @default.
- W2157525101 cites W1565276921 @default.
- W2157525101 cites W1968132461 @default.
- W2157525101 cites W1972219003 @default.
- W2157525101 cites W1973682477 @default.
- W2157525101 cites W1975721281 @default.
- W2157525101 cites W1977181213 @default.
- W2157525101 cites W1983210338 @default.
- W2157525101 cites W1998927459 @default.
- W2157525101 cites W2000275869 @default.
- W2157525101 cites W2011908176 @default.
- W2157525101 cites W2019891348 @default.
- W2157525101 cites W2022797070 @default.
- W2157525101 cites W2023096047 @default.
- W2157525101 cites W2027003058 @default.
- W2157525101 cites W2034505366 @default.
- W2157525101 cites W2043289446 @default.
- W2157525101 cites W2051301080 @default.
- W2157525101 cites W2056600819 @default.
- W2157525101 cites W2064571996 @default.
- W2157525101 cites W2066851924 @default.
- W2157525101 cites W2067453181 @default.
- W2157525101 cites W2090642125 @default.
- W2157525101 cites W2092400856 @default.
- W2157525101 cites W2095673758 @default.
- W2157525101 cites W2096459935 @default.
- W2157525101 cites W2105017286 @default.
- W2157525101 cites W2106261345 @default.
- W2157525101 cites W2106787323 @default.
- W2157525101 cites W2106835969 @default.
- W2157525101 cites W2112899213 @default.
- W2157525101 cites W2117277750 @default.
- W2157525101 cites W2121289368 @default.
- W2157525101 cites W2123467283 @default.
- W2157525101 cites W2128562119 @default.
- W2157525101 cites W2134389439 @default.
- W2157525101 cites W2142850268 @default.
- W2157525101 cites W2154833261 @default.
- W2157525101 cites W2157492758 @default.
- W2157525101 cites W2163101954 @default.
- W2157525101 cites W2167244585 @default.
- W2157525101 cites W2167570886 @default.
- W2157525101 cites W2803327664 @default.
- W2157525101 cites W4230235331 @default.
- W2157525101 cites W4293166735 @default.
- W2157525101 cites W4372182623 @default.
- W2157525101 doi "https://doi.org/10.1111/hpb.12017" @default.
- W2157525101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731581" @default.
- W2157525101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23458426" @default.
- W2157525101 hasPublicationYear "2013" @default.
- W2157525101 type Work @default.
- W2157525101 sameAs 2157525101 @default.
- W2157525101 citedByCount "8" @default.
- W2157525101 countsByYear W21575251012014 @default.
- W2157525101 countsByYear W21575251012015 @default.
- W2157525101 countsByYear W21575251012016 @default.
- W2157525101 countsByYear W21575251012019 @default.
- W2157525101 countsByYear W21575251012020 @default.
- W2157525101 countsByYear W21575251012021 @default.
- W2157525101 crossrefType "journal-article" @default.
- W2157525101 hasAuthorship W2157525101A5002727500 @default.
- W2157525101 hasAuthorship W2157525101A5010756339 @default.
- W2157525101 hasAuthorship W2157525101A5031930566 @default.
- W2157525101 hasAuthorship W2157525101A5039947825 @default.
- W2157525101 hasAuthorship W2157525101A5049672570 @default.
- W2157525101 hasAuthorship W2157525101A5052876669 @default.
- W2157525101 hasAuthorship W2157525101A5081893214 @default.
- W2157525101 hasAuthorship W2157525101A5084721292 @default.
- W2157525101 hasAuthorship W2157525101A5084788672 @default.
- W2157525101 hasBestOaLocation W21575251011 @default.
- W2157525101 hasConcept C119128265 @default.
- W2157525101 hasConcept C121608353 @default.
- W2157525101 hasConcept C126322002 @default.
- W2157525101 hasConcept C154945302 @default.
- W2157525101 hasConcept C185592680 @default.
- W2157525101 hasConcept C23531484 @default.
- W2157525101 hasConcept C2780210213 @default.
- W2157525101 hasConcept C2908647359 @default.
- W2157525101 hasConcept C41008148 @default.
- W2157525101 hasConcept C43617362 @default.
- W2157525101 hasConcept C69738355 @default.
- W2157525101 hasConcept C71924100 @default.
- W2157525101 hasConcept C76318530 @default.
- W2157525101 hasConcept C99454951 @default.
- W2157525101 hasConceptScore W2157525101C119128265 @default.