FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157540595> ?p ?o ?g. }

• W2157540595 abstract "A previous study demonstrated for the first time that a drug such as caffeine, administered prior to ovulation and genomic activation, causes a quantitative difference in growth-promoting energy utilization in a proportion of 5-day-old blastocysts. The objective of the present study was to investigate whether developmental changes induced by caffeine administered throughout the estrus cycle prior to fertilization are sustained throughout pregnancy and after birth.Caffeine was administered to rats throughout the estrus cycle prior to fertilization, with control and experimental groups subdivided into preimplantation and postimplantation categories. Preimplantation fertilization rate was assessed on day 4 of pregnancy by a pregnancy-induced elevation in maternal plasma progesterone concentration, or by flushing each uterine horn on day 5 of pregnancy to determine the presence or absence of a litter. Postimplantation fetuses were collected on gestational day 12 or allowed to go to term.Preconceptual caffeine exposure significantly reduced maternal fertility by the failure of a proportion of the litters to implant, rather than curtailing preimplantation development or postimplantation losses. Postnatal mortality between weeks 0 and 1 was elevated and the weekly incremental growth rate of the pups from week 3 through week 7 was significantly reduced in the preconceptually caffeine-treated offspring. Experimental females reached puberty at the same age as the controls but at a significantly lower body weight. Gestation length, hirthweight, litter size, sex ratio, and anogenital distance (a measure of prenatal androgenization) were not affected by preconceptual caffeine treatment.It was concluded that the reduced fertility rate in preconceptually caffeine-exposed rats was due to the failure of litters to implant rather than to a reduced fertilization rate, which was normal. It was further concluded that the growth rate over the neonatal and prepubertal periods of surviving pups in the caffeine-treated group was subnormal." @default.
• W2157540595 created "2016-06-24" @default.
• W2157540595 creator A5024089042 @default.
• W2157540595 creator A5037653346 @default.
• W2157540595 creator A5048774392 @default.
• W2157540595 creator A5064348526 @default.
• W2157540595 creator A5085023551 @default.
• W2157540595 date "1999-09-01" @default.
• W2157540595 modified "2023-09-27" @default.
• W2157540595 title "Effects of preconceptual caffeine exposure on pregnancy and progeny viability" @default.
• W2157540595 cites W1804317722 @default.
• W2157540595 cites W1970497695 @default.
• W2157540595 cites W1976926829 @default.
• W2157540595 cites W1978540918 @default.
• W2157540595 cites W1988666107 @default.
• W2157540595 cites W1994212260 @default.
• W2157540595 cites W2001646489 @default.
• W2157540595 cites W2031316752 @default.
• W2157540595 cites W2055614521 @default.
• W2157540595 cites W2057524649 @default.
• W2157540595 cites W2074896250 @default.
• W2157540595 cites W2080520032 @default.
• W2157540595 cites W2083552793 @default.
• W2157540595 cites W2087734715 @default.
• W2157540595 cites W2139743744 @default.
• W2157540595 cites W4240906978 @default.
• W2157540595 doi "https://doi.org/10.1002/(sici)1520-6661(199909/10)8:5<220::aid-mfm4>3.0.co;2-w" @default.
• W2157540595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10475504" @default.
• W2157540595 hasPublicationYear "1999" @default.
• W2157540595 type Work @default.
• W2157540595 sameAs 2157540595 @default.
• W2157540595 citedByCount "12" @default.
• W2157540595 countsByYear W21575405952012 @default.
• W2157540595 countsByYear W21575405952013 @default.
• W2157540595 countsByYear W21575405952014 @default.
• W2157540595 countsByYear W21575405952015 @default.
• W2157540595 crossrefType "journal-article" @default.
• W2157540595 hasAuthorship W2157540595A5024089042 @default.
• W2157540595 hasAuthorship W2157540595A5037653346 @default.
• W2157540595 hasAuthorship W2157540595A5048774392 @default.
• W2157540595 hasAuthorship W2157540595A5064348526 @default.
• W2157540595 hasAuthorship W2157540595A5085023551 @default.
• W2157540595 hasConcept C105702510 @default.
• W2157540595 hasConcept C134018914 @default.
• W2157540595 hasConcept C140793950 @default.
• W2157540595 hasConcept C16685009 @default.
• W2157540595 hasConcept C1998276 @default.
• W2157540595 hasConcept C2777702977 @default.
• W2157540595 hasConcept C2778500429 @default.
• W2157540595 hasConcept C2779234561 @default.
• W2157540595 hasConcept C2779429622 @default.
• W2157540595 hasConcept C42407357 @default.
• W2157540595 hasConcept C46973012 @default.
• W2157540595 hasConcept C54355233 @default.
• W2157540595 hasConcept C6557445 @default.
• W2157540595 hasConcept C71924100 @default.
• W2157540595 hasConcept C86803240 @default.
• W2157540595 hasConcept C88972607 @default.
• W2157540595 hasConceptScore W2157540595C105702510 @default.
• W2157540595 hasConceptScore W2157540595C134018914 @default.
• W2157540595 hasConceptScore W2157540595C140793950 @default.
• W2157540595 hasConceptScore W2157540595C16685009 @default.
• W2157540595 hasConceptScore W2157540595C1998276 @default.
• W2157540595 hasConceptScore W2157540595C2777702977 @default.
• W2157540595 hasConceptScore W2157540595C2778500429 @default.
• W2157540595 hasConceptScore W2157540595C2779234561 @default.
• W2157540595 hasConceptScore W2157540595C2779429622 @default.
• W2157540595 hasConceptScore W2157540595C42407357 @default.
• W2157540595 hasConceptScore W2157540595C46973012 @default.
• W2157540595 hasConceptScore W2157540595C54355233 @default.
• W2157540595 hasConceptScore W2157540595C6557445 @default.
• W2157540595 hasConceptScore W2157540595C71924100 @default.
• W2157540595 hasConceptScore W2157540595C86803240 @default.
• W2157540595 hasConceptScore W2157540595C88972607 @default.
• W2157540595 hasLocation W21575405951 @default.
• W2157540595 hasLocation W21575405952 @default.
• W2157540595 hasOpenAccess W2157540595 @default.
• W2157540595 hasPrimaryLocation W21575405951 @default.
• W2157540595 hasRelatedWork W1815171130 @default.
• W2157540595 hasRelatedWork W1983412563 @default.
• W2157540595 hasRelatedWork W1988557535 @default.
• W2157540595 hasRelatedWork W2004041728 @default.
• W2157540595 hasRelatedWork W2019234790 @default.
• W2157540595 hasRelatedWork W2030681448 @default.
• W2157540595 hasRelatedWork W2038506395 @default.
• W2157540595 hasRelatedWork W2057720991 @default.
• W2157540595 hasRelatedWork W2074651814 @default.
• W2157540595 hasRelatedWork W2080520032 @default.
• W2157540595 hasRelatedWork W2296079351 @default.
• W2157540595 hasRelatedWork W2350966116 @default.
• W2157540595 hasRelatedWork W2401432909 @default.
• W2157540595 hasRelatedWork W2413671961 @default.
• W2157540595 hasRelatedWork W2413901583 @default.
• W2157540595 hasRelatedWork W2939760243 @default.
• W2157540595 hasRelatedWork W2996901679 @default.
• W2157540595 hasRelatedWork W3030040024 @default.
• W2157540595 hasRelatedWork W2100284620 @default.
• W2157540595 hasRelatedWork W5670118 @default.
• W2157540595 isParatext "false" @default.
• W2157540595 isRetracted "false" @default.

• next