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- W2157549846 abstract "On treatment with collagenase, brain microvessels, together with several protein components, lose some enzymatic activities such as alkaline phosphatase and γ-glutamyltranspeptidase, whereas no change occurs in the activities of 5′-nucleotidase and glutamine synthetase. The energy-requiring „A-system” of polar neutral amino acid transport is also severely inactivated, whereas the L-system for the facilitated exchange of branched chain and aromatic amino acids is preserved. In the collagenase-digested microvessels, this leads to loss of the transtimulation effect of glutamine on the transport of large neutral amino acids, because such transtimulation is due to a cooperation between the A- and L-systems. By contrast, NH4+ maintains (and even enhances) its ability to stimulate the L-system of amino acid transport, presumably through glutamine synthesis within the endothelial cells." @default.
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- W2157549846 date "1987-12-01" @default.
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- W2157549846 title "Isolated Brain Microvessels as In Vitro Equivalents of the Blood-Brain Barrier: Selective Removal by Collagenase of the A-System of Neutral Amino Acid Transport" @default.
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- W2157549846 doi "https://doi.org/10.1111/j.1471-4159.1987.tb02424.x" @default.
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