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- W2157560491 abstract "Interleukin (IL) 10 deficiency is notable in cystic fibrosis (CF) bronchoalveolar lavage (BAL) fluid. Similar airway neutrophils did not inhibit IL-8 production with IL-10 exposure. This study describes the complex response of CF airway immune cells to recombinant IL-10 exposure when compared to non-CF patients. BAL fluid was obtained from 11 CF and 3 non-CF pediatric subjects and immediately centrifuged at 1,000 rpm for 10 min. The cells were resuspended to a final concentration of 1×106 cells/mL. Aliquots of the cells were incubated with 0, 10, 100, and 1,000 ng/mL of recombinant human IL-10 for 24 h. Supernatants were obtained and enzyme-linked immunosorbent assay performed for levels of IL-8, IL-1β, and tumor necrosis factor alpha (TNFα) cytokines. CF patients (n=11) showed statistically significant percent inhibition of IL-8 at IL-10 level at 10 ng/mL (34.7%, P<0.001) and 100 ng/mL (45.9%, P=0.001), though no statistically significant inhibition noted at 1,000 ng/mL. IL-1β did not show statistically significant percent inhibition at any concentration. TNFα revealed a percent inhibition at IL-10 level of 10 ng/mL (52.4%, P=0.002) and 100 ng/mL (61.0%, P<0.001) and no statistically significant inhibition at 1,000 ng/mL. CF and controls (n=3) were marginally different for IL-1β, but showed no statistically significant difference in percent inhibition for IL-8 and TNFα. CF airway immune cell cytokines demonstrate a similar response to IL-10 as non-CF controls with notable differential suppression of IL-8 and TNFα, though not IL-1β. IL-10 resistant airway cells are less likely to be the cause of CF pulmonary hyperinflammation." @default.
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- W2157560491 date "2012-12-01" @default.
- W2157560491 modified "2023-09-23" @default.
- W2157560491 title "Inflammatory Cytokines of Cystic Fibrosis Airway Cells Are Reduced with Exposure to Interleukin-10" @default.
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- W2157560491 doi "https://doi.org/10.1089/ped.2012.0160" @default.
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