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• W2157569401 abstract "TC10 is a member of the Rho family of small GTP-binding proteins that has previously been implicated in the regulation of insulin-stimulated GLUT4 translocation in adipocytes. In a manner similar to Cdc42-stimulated actin-based motility, we have observed that constitutively active TC10 (TC10/Q75L) can induce actin comet tails in Xenopus oocyte extracts in vitro and extensive actin polymerization in the perinuclear region when expressed in 3T3L1 adipocytes. In contrast, expression of TC10/Q75L completely disrupted adipocyte cortical actin, which was specific for TC10, because expression of constitutively active Cdc42 was without effect. The effect of TC10/Q75L to disrupt cortical actin was abrogated after deletion of the amino terminal extension (DeltaN-TC10/Q75L), whereas this deletion retained the ability to induce perinuclear actin polymerization. In addition, alteration of perinuclear actin by expression of TC10/Q75L, a dominant-interfering TC10/T31N mutant or a mutant N-WASP protein (N-WASP/DeltaVCA) reduced the rate of VSV G protein trafficking to the plasma membrane. Furthermore, TC10 directly bound to Golgi COPI coat proteins through a dilysine motif in the carboxyl terminal domain consistent with a role for TC10 regulating actin polymerization on membrane transport vesicles. Together, these data demonstrate that TC10 can differentially regulate two types of filamentous actin in adipocytes dependent on distinct functional domains and its subcellular compartmentalization." @default.
• W2157569401 created "2016-06-24" @default.
• W2157569401 creator A5018176504 @default.
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• W2157569401 date "2002-07-01" @default.
• W2157569401 modified "2023-10-16" @default.
• W2157569401 title "Small GTP-binding Protein TC10 Differentially Regulates Two Distinct Populations of Filamentous Actin in 3T3L1 Adipocytes" @default.
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• W2157569401 doi "https://doi.org/10.1091/mbc.01-10-0490" @default.
• W2157569401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/117317" @default.
• W2157569401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12134073" @default.
• W2157569401 hasPublicationYear "2002" @default.
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