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• W2157569542 abstract "Objective We investigated the usefulness of serum cardiac Troponin T (cTnT) to detect doxorubicin related cardiotoxicity as a non-invasive and reliable method. Patients and Methods Twenty-four patients who received doxorubicin for their solid tumors at cumulative doses of 400 mg/m2 or higher, between June 1982 and August 2000, were included in this study. None of them had clinical signs or symptoms of cardiotoxicity. The age range was 3–31 years (median 14), and male to female ratio was 14/10. The systolic and diastolic cardiac functions were evaluated by two-dimensional, M-mode, and Doppler echocardiography. Serum cTnT levels were measured by a third generation immunoassay method and the lowest detectable level was 0.010 ng/ml. Results The cumulative doxorubicin doses were at the range of 400 and 840 mg/m2 (median 480). The time past from the last doxorubicin dose was 1–168 months (median 12). All of the patients had normal chest X-rays, electrocardiograms, and nine patients (37.5%) had abnormal systolic or diastolic cardiac function parameters. The median cumulative doxorubicin doses of the patients with normal and abnormal echocardiographic parameters were 480 and 440 mg/m2, respectively. Serum cTnT values of 21 patients were below the detection limit (< 0.010 ng/ml). There was no statistical difference between serum cTnT levels of the patients with normal and abnormal echocardiographic findings (P = 0.376). Conclusions No correlation was found between serum cTnT values, cumulative doxorubicin doses, and systolic or diastolic cardiac functions. We can conclude that echocardiographic follow-up is more reliable than serum cTnT levels for detecting subclinical cardiac toxicity. © 2003 Wiley-Liss, Inc." @default.
• W2157569542 created "2016-06-24" @default.
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• W2157569542 date "2003-10-29" @default.
• W2157569542 modified "2023-10-14" @default.
• W2157569542 title "Serum troponin T levels and echocardiographic evaluation in children treated with doxorubicin" @default.
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• W2157569542 doi "https://doi.org/10.1002/pbc.10368" @default.
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