FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157618054> ?p ?o ?g. }

• W2157618054 endingPage "657" @default.
• W2157618054 startingPage "651" @default.
• W2157618054 abstract "PurposeLi-Fraumeni syndrome is a rare hereditary cancer syndrome associated with germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast and adrenal cortical carcinomas are typically recognized as Li-Fraumeni syndrome-associated tumors, the occurrence of gastrointestinal neoplasms has not been fully evaluated. In this analysis, we investigated the frequency and characteristics of gastric cancer in Li-Fraumeni syndrome.MethodsPedigrees and medical records of 62 TP53 mutation-positive families were retrospectively reviewed from the Dana-Farber/National Cancer Institute Li-Fraumeni syndrome registry. We identified subjects with gastric cancer documented either by pathology report or death certificate and performed pathology review of the available specimens.ResultsAmong 62 TP53 mutation-positive families, there were 429 cancer-affected individuals. Gastric cancer was the diagnosis in the lineages of 21 (4.9%) subjects from 14 families (22.6%). The mean and median ages at gastric cancer diagnosis were 43 and 36 years, respectively (range: 24–74 years), significantly younger compared with the median age at diagnosis in the general population based on Surveillance Epidemiology and End Results data (71 years). Five (8.1%) families reported two or more cases of gastric cancer, and six (9.7%) families had cases of both colorectal and gastric cancers. No association was seen between phenotype and type/location of the TP53 mutations. Pathology review of the available tumors revealed both intestinal and diffuse histologies.ConclusionsEarly-onset gastric cancer seems to be a component of Li-Fraumeni syndrome, suggesting the need for early and regular endoscopic screening in individuals with germline TP53 mutations, particularly among those with a family history of gastric cancer." @default.
• W2157618054 created "2016-06-24" @default.
• W2157618054 creator A5004443306 @default.
• W2157618054 creator A5005206482 @default.
• W2157618054 creator A5008115481 @default.
• W2157618054 creator A5010898844 @default.
• W2157618054 creator A5035763230 @default.
• W2157618054 creator A5037716901 @default.
• W2157618054 creator A5038045975 @default.
• W2157618054 creator A5043315482 @default.
• W2157618054 creator A5044829924 @default.
• W2157618054 creator A5045183789 @default.
• W2157618054 creator A5060496937 @default.
• W2157618054 creator A5060959734 @default.
• W2157618054 creator A5062999902 @default.
• W2157618054 creator A5063879697 @default.
• W2157618054 creator A5079620607 @default.
• W2157618054 creator A5086204990 @default.
• W2157618054 date "2011-07-01" @default.
• W2157618054 modified "2023-10-18" @default.
• W2157618054 title "Gastric cancer in individuals with Li-Fraumeni syndrome" @default.
• W2157618054 cites W1514348119 @default.
• W2157618054 cites W1515121932 @default.
• W2157618054 cites W1542351647 @default.
• W2157618054 cites W1596222665 @default.
• W2157618054 cites W1651458958 @default.
• W2157618054 cites W1905081637 @default.
• W2157618054 cites W1922618037 @default.
• W2157618054 cites W1938158279 @default.
• W2157618054 cites W1938299812 @default.
• W2157618054 cites W1977844138 @default.
• W2157618054 cites W1979488027 @default.
• W2157618054 cites W1979505082 @default.
• W2157618054 cites W1985095144 @default.
• W2157618054 cites W1999579934 @default.
• W2157618054 cites W2003090246 @default.
• W2157618054 cites W2005582722 @default.
• W2157618054 cites W2007023752 @default.
• W2157618054 cites W2015785607 @default.
• W2157618054 cites W2027206828 @default.
• W2157618054 cites W2029186878 @default.
• W2157618054 cites W2040989154 @default.
• W2157618054 cites W2050729751 @default.
• W2157618054 cites W2051611229 @default.
• W2157618054 cites W2059284780 @default.
• W2157618054 cites W2069117283 @default.
• W2157618054 cites W2074177998 @default.
• W2157618054 cites W2097132292 @default.
• W2157618054 cites W2112279932 @default.
• W2157618054 cites W2116366831 @default.
• W2157618054 cites W2119480806 @default.
• W2157618054 cites W2120941813 @default.
• W2157618054 cites W2128722826 @default.
• W2157618054 cites W2140986588 @default.
• W2157618054 cites W2147132202 @default.
• W2157618054 cites W2185214171 @default.
• W2157618054 cites W2338576041 @default.
• W2157618054 cites W2439574920 @default.
• W2157618054 cites W3140518968 @default.
• W2157618054 doi "https://doi.org/10.1097/gim.0b013e31821628b6" @default.
• W2157618054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595598" @default.
• W2157618054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21552135" @default.
• W2157618054 hasPublicationYear "2011" @default.
• W2157618054 type Work @default.
• W2157618054 sameAs 2157618054 @default.
• W2157618054 citedByCount "116" @default.
• W2157618054 countsByYear W21576180542012 @default.
• W2157618054 countsByYear W21576180542013 @default.
• W2157618054 countsByYear W21576180542014 @default.
• W2157618054 countsByYear W21576180542015 @default.
• W2157618054 countsByYear W21576180542016 @default.
• W2157618054 countsByYear W21576180542017 @default.
• W2157618054 countsByYear W21576180542018 @default.
• W2157618054 countsByYear W21576180542019 @default.
• W2157618054 countsByYear W21576180542020 @default.
• W2157618054 countsByYear W21576180542021 @default.
• W2157618054 countsByYear W21576180542022 @default.
• W2157618054 countsByYear W21576180542023 @default.
• W2157618054 crossrefType "journal-article" @default.
• W2157618054 hasAuthorship W2157618054A5004443306 @default.
• W2157618054 hasAuthorship W2157618054A5005206482 @default.
• W2157618054 hasAuthorship W2157618054A5008115481 @default.
• W2157618054 hasAuthorship W2157618054A5010898844 @default.
• W2157618054 hasAuthorship W2157618054A5035763230 @default.
• W2157618054 hasAuthorship W2157618054A5037716901 @default.
• W2157618054 hasAuthorship W2157618054A5038045975 @default.
• W2157618054 hasAuthorship W2157618054A5043315482 @default.
• W2157618054 hasAuthorship W2157618054A5044829924 @default.
• W2157618054 hasAuthorship W2157618054A5045183789 @default.
• W2157618054 hasAuthorship W2157618054A5060496937 @default.
• W2157618054 hasAuthorship W2157618054A5060959734 @default.
• W2157618054 hasAuthorship W2157618054A5062999902 @default.
• W2157618054 hasAuthorship W2157618054A5063879697 @default.
• W2157618054 hasAuthorship W2157618054A5079620607 @default.
• W2157618054 hasAuthorship W2157618054A5086204990 @default.
• W2157618054 hasBestOaLocation W21576180541 @default.
• W2157618054 hasConcept C104317684 @default.
• W2157618054 hasConcept C121608353 @default.

• next