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• W2157624459 abstract "Decreased activity of oxygen-sensitive potassium (K) channels reduces hypoxia-induced contraction of pulmonary vascular tissue. Oxygen-sensitive channels are present in the fetoplacental vasculature, where vascular resistance is thought to increase in fetal growth restriction (FGR). We assessed placental gene expression of K(V)2.1, K(V)9.3 and K(IR)6.1, three oxygen-sensitive K channels in normal pregnancy and FGR.Biopsies were obtained from 12 normal pregnancies and 12 pregnancies complicated by FGR. Chorionic plate arteries and veins were dissected from the biopsies and a sample of placental tissue comprising chorionic plate and villus tissue was also collected. All samples were processed and analyzed using real time quantitative RT-PCR.K(V)2.1 and K(V)9.3 gene expression, in veins and placental homogenate, respectively, were increased in FGR. K(IR)6.1 gene expression was comparable in normal pregnancy and FGR samples.The gene expression of two voltage-gated K channels thought to be important for altered vascular reactivity following changes in oxygenation is increased in FGR." @default.
• W2157624459 created "2016-06-24" @default.
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• W2157624459 date "2008-01-01" @default.
• W2157624459 modified "2023-09-27" @default.
• W2157624459 title "Altered Potassium Channel Expression in the Human Placental Vasculature of Pregnancies Complicated by Fetal Growth Restriction" @default.
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• W2157624459 doi "https://doi.org/10.1080/10641950701826158" @default.
• W2157624459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18293206" @default.
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