FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157629181> ?p ?o ?g. }

• W2157629181 endingPage "e135" @default.
• W2157629181 startingPage "e128" @default.
• W2157629181 abstract "1. Acute myocardial infarction (AMI) is strongly associated with atherosclerosis, and is responsible for significant morbidity and mortality worldwide. The pathogenic mechanisms that underlie atherosclerosis and AMI are undefined at present. The calcium-sensing receptor (CaSR) is a member of the superfamily of G-protein coupled receptors. It has been demonstrated previously that the expression of CaSR is increased in atherosclerotic cardiac tissue of rats. It has also been suggested that CaSR has a crucial role in cardiac ischaemia–reperfusion injury, apoptosis and hypertrophy. However, it remains to be determined whether an increase in the expression of CaSR influences the sensitivity of cardiomyocytes to AMI. 2. The present study used cultured ventricular cardiomyocytes from neonatal rats to investigate the effect of oxidized low-density lipoprotein (ox-LDL), ischaemia–reperfusion, GdCl3 (an agonist of CaSR) and NPS-2390 (an antagonist of CaSR) on the expression of CaSR. The amount of apoptosis, alterations in the morphology of the cells, the intracellular calcium concentration ([Ca2+]i) and components of critical mitochondrial pathways were also analysed. 3. Cardiomyocytes treated with ox-LDL showed upregulated expression of CaSR, cytochrome c (cyt-c), Bax and activated caspase 3 (17 kD) and downregulated expression of Bcl-2, as well as elevated [Ca2+]i and apoptosis. Application of GdCl3 augmented these effects, and NPS-2390 decreased the expression of CaSR and reduced apoptosis. 4. In conclusion, ox-LDL was found to increase the expression of CaSR in a manner that was dependent on time and dose. It also augmented apoptosis during simulated ischaemia–reperfusion in cultured ventricular cardiomyocytes from neonatal rats." @default.
• W2157629181 created "2016-06-24" @default.
• W2157629181 creator A5015926213 @default.
• W2157629181 creator A5017366969 @default.
• W2157629181 creator A5040924323 @default.
• W2157629181 creator A5041324566 @default.
• W2157629181 creator A5042263308 @default.
• W2157629181 creator A5042947574 @default.
• W2157629181 creator A5049482193 @default.
• W2157629181 creator A5066716873 @default.
• W2157629181 creator A5070812231 @default.
• W2157629181 creator A5077196517 @default.
• W2157629181 creator A5083508487 @default.
• W2157629181 creator A5084688862 @default.
• W2157629181 date "2010-03-01" @default.
• W2157629181 modified "2023-10-17" @default.
• W2157629181 title "Increased expression of calcium-sensing receptors induced by ox-LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia-reperfusion" @default.
• W2157629181 cites W1992744578 @default.
• W2157629181 cites W2001737862 @default.
• W2157629181 cites W2002503549 @default.
• W2157629181 cites W2014285040 @default.
• W2157629181 cites W2018210356 @default.
• W2157629181 cites W2018356010 @default.
• W2157629181 cites W2037386069 @default.
• W2157629181 cites W2038142591 @default.
• W2157629181 cites W2050930581 @default.
• W2157629181 cites W2066598065 @default.
• W2157629181 cites W2067466593 @default.
• W2157629181 cites W2070764343 @default.
• W2157629181 cites W2093706823 @default.
• W2157629181 cites W2096997379 @default.
• W2157629181 cites W2106856165 @default.
• W2157629181 cites W2117123684 @default.
• W2157629181 cites W2125441169 @default.
• W2157629181 cites W2128936019 @default.
• W2157629181 cites W2140321883 @default.
• W2157629181 cites W2146684396 @default.
• W2157629181 cites W2156911663 @default.
• W2157629181 cites W2158020124 @default.
• W2157629181 cites W2170347547 @default.
• W2157629181 cites W89430380 @default.
• W2157629181 doi "https://doi.org/10.1111/j.1440-1681.2010.05345.x" @default.
• W2157629181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20409080" @default.
• W2157629181 hasPublicationYear "2010" @default.
• W2157629181 type Work @default.
• W2157629181 sameAs 2157629181 @default.
• W2157629181 citedByCount "30" @default.
• W2157629181 countsByYear W21576291812012 @default.
• W2157629181 countsByYear W21576291812013 @default.
• W2157629181 countsByYear W21576291812014 @default.
• W2157629181 countsByYear W21576291812016 @default.
• W2157629181 countsByYear W21576291812017 @default.
• W2157629181 countsByYear W21576291812018 @default.
• W2157629181 countsByYear W21576291812019 @default.
• W2157629181 countsByYear W21576291812020 @default.
• W2157629181 countsByYear W21576291812021 @default.
• W2157629181 countsByYear W21576291812022 @default.
• W2157629181 countsByYear W21576291812023 @default.
• W2157629181 crossrefType "journal-article" @default.
• W2157629181 hasAuthorship W2157629181A5015926213 @default.
• W2157629181 hasAuthorship W2157629181A5017366969 @default.
• W2157629181 hasAuthorship W2157629181A5040924323 @default.
• W2157629181 hasAuthorship W2157629181A5041324566 @default.
• W2157629181 hasAuthorship W2157629181A5042263308 @default.
• W2157629181 hasAuthorship W2157629181A5042947574 @default.
• W2157629181 hasAuthorship W2157629181A5049482193 @default.
• W2157629181 hasAuthorship W2157629181A5066716873 @default.
• W2157629181 hasAuthorship W2157629181A5070812231 @default.
• W2157629181 hasAuthorship W2157629181A5077196517 @default.
• W2157629181 hasAuthorship W2157629181A5083508487 @default.
• W2157629181 hasAuthorship W2157629181A5084688862 @default.
• W2157629181 hasConcept C104317684 @default.
• W2157629181 hasConcept C126322002 @default.
• W2157629181 hasConcept C127561419 @default.
• W2157629181 hasConcept C134018914 @default.
• W2157629181 hasConcept C142590548 @default.
• W2157629181 hasConcept C170493617 @default.
• W2157629181 hasConcept C181080969 @default.
• W2157629181 hasConcept C185592680 @default.
• W2157629181 hasConcept C190283241 @default.
• W2157629181 hasConcept C2776885963 @default.
• W2157629181 hasConcept C2778938600 @default.
• W2157629181 hasConcept C2780114680 @default.
• W2157629181 hasConcept C29311851 @default.
• W2157629181 hasConcept C519063684 @default.
• W2157629181 hasConcept C541997718 @default.
• W2157629181 hasConcept C55493867 @default.
• W2157629181 hasConcept C71924100 @default.
• W2157629181 hasConcept C79879829 @default.
• W2157629181 hasConcept C86803240 @default.
• W2157629181 hasConcept C87975464 @default.
• W2157629181 hasConcept C95444343 @default.
• W2157629181 hasConceptScore W2157629181C104317684 @default.
• W2157629181 hasConceptScore W2157629181C126322002 @default.
• W2157629181 hasConceptScore W2157629181C127561419 @default.
• W2157629181 hasConceptScore W2157629181C134018914 @default.
• W2157629181 hasConceptScore W2157629181C142590548 @default.
• W2157629181 hasConceptScore W2157629181C170493617 @default.

• next