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• W2157660669 abstract "Depression is increasingly recognised as a major public health problem worldwide. The heterogeneity of this condition implies that there may be several neurobiological pathways to depression. This article attempts to explore a pathway that links depression with the inflammatory response. Associations linking inflammation and chronic immune activation with depression have been noted, particularly in the context of (a) medical disorders with inflammatory pathophysiology and (b) immunotherapy for cancer and hepatitis C. Acute coronary syndrome is given as an example of how the inflammatory process might result in depression, and potential mechanisms are discussed. These include: direct action of pro-inflammatory cytokines on the serotonin system, with specific reference to the serotonin transporter; action of cytokines on the hypothalamic–pituitary–adrenal axis; and effects of pro-inflammatory cytokines on neurogenesis in the hippocampus. Reference is made to the potential anti-inflammatory effects of antidepressant drugs and antidepressant effects of anti-inflammatory treatments." @default.
• W2157660669 created "2016-06-24" @default.
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• W2157660669 date "2008-07-01" @default.
• W2157660669 modified "2023-10-06" @default.
• W2157660669 title "Inflammation and its relevance to psychiatry" @default.
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• W2157660669 doi "https://doi.org/10.1192/apt.bp.106.003319" @default.
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