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- W2157673325 abstract "The Hippo signaling pathway is involved in regulating tissue size by inhibiting cell proliferation and promoting apoptosis. Aberrant Hippo pathway function is often detected in human cancers and correlates with poor prognosis. The Drosophila C-terminal Src kinase (d-Csk) is a genetic modifier of warts (wts), a tumor-suppressor gene in the Hippo pathway, and interacts with the Src oncogene. Reduction in d-Csk expression and the consequent activation of Src are frequently seen in several cancers including hepatocellular and colorectal tumors. Previous studies show that d-Csk regulates cell proliferation and tissue size during development. Given the similarity in the loss-of-function phenotypes of d-Csk and wts, we have investigated the interactions of d-Csk with the Hippo pathway. Here we present multiple lines of evidence suggesting that d-Csk regulates growth via the Hippo signaling pathway. We show that loss of dCsk caused increased Yki activity, and our genetic epistasis places dCsk downstream of Dachs. Furthermore, dCsk requires Yki for its growth regulatory functions, suggesting that dCsk is another upstream member of the network of genes that interact to regulate Wts and its effector Yki in the Hippo signaling pathway." @default.
- W2157673325 created "2016-06-24" @default.
- W2157673325 creator A5019866026 @default.
- W2157673325 creator A5039249322 @default.
- W2157673325 creator A5063266260 @default.
- W2157673325 creator A5065536524 @default.
- W2157673325 creator A5067603018 @default.
- W2157673325 creator A5077617433 @default.
- W2157673325 date "2015-01-01" @default.
- W2157673325 modified "2023-09-27" @default.
- W2157673325 title "Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway" @default.
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- W2157673325 doi "https://doi.org/10.1016/j.ydbio.2014.10.010" @default.
- W2157673325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446534" @default.
- W2157673325 hasPublicationYear "2015" @default.
- W2157673325 type Work @default.