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• W2157675345 abstract "The integration of multiple developmental cues is crucial to the combinatorial strategies for cell specification that underlie metazoan development. In the Drosophila genital imaginal disc, which gives rise to the sexually dimorphic genitalia and analia, sexual identity must be integrated with positional cues, in order to direct the appropriate sexually dimorphic developmental program. Sex determination in Drosophila is controlled by a hierarchy of regulatory genes. The last known gene in the somatic branch of this hierarchy is the transcription factor doublesex (dsx); however, targets of the hierarchy that play a role in sexually dimorphic development have remained elusive. We show that the gene dachshund (dac) is differentially expressed in the male and female genital discs, and plays sex-specific roles in the development of the genitalia. Furthermore, the sex determination hierarchy mediates this sex-specific deployment of dac by modulating the regulation of dac by the pattern formation genes wingless (wg) and decapentaplegic (dpp). We find that the sex determination pathway acts cell-autonomously to determine whether dac is activated by wg signaling, as in females, or by dpp signaling, as in males." @default.
• W2157675345 created "2016-06-24" @default.
• W2157675345 creator A5006940807 @default.
• W2157675345 creator A5016562360 @default.
• W2157675345 date "2001-05-01" @default.
• W2157675345 modified "2023-10-14" @default.
• W2157675345 title "The <i>Drosophila</i> sex determination hierarchy modulates <i>wingless</i> and <i>decapentaplegic</i> signaling to deploy <i>dachshund</i> sex-specifically in the genital imaginal disc" @default.
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• W2157675345 doi "https://doi.org/10.1242/dev.128.9.1643" @default.
• W2157675345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11290302" @default.
• W2157675345 hasPublicationYear "2001" @default.
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