FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157717340> ?p ?o ?g. }

• W2157717340 endingPage "143" @default.
• W2157717340 startingPage "133" @default.
• W2157717340 abstract "Abstract Efficient transcription of ribosomal protein (RP) and glycolytic genes requires the Rap1p/Gcr1p regulatory complex. A third factor, Gcr2p, is required for only the glycolytic (specialized) mode of transcriptional activation. It is recruited to the complex by Gcr1p and likely mediates a change in the phosphorylation state and/or conformation of the latter. We show here that leucine zipper motifs in Gcr1p and Gcr2p (1LZ and 2LZ) are each specific to one of the two activation mechanisms—mutations in 1LZ and 2LZ impair transcription of RP and glycolytic genes, respectively. Although neither class of mutations causes more than a mild growth defect, simultaneous impairment of 1LZ and 2LZ results in a severe synthetic defect and a reduction in the expression of both sets of genes. Intracistronic complementation by point mutations in the charged e and g positions confirmed that Gcr1p/Gcr1p and Gcr2p/Gcr2p homodimers are the forms required for the different roles of the activator complex. Direct heterodimerization between 1LZ and 2LZ apparently does not occur. Dichotomous Rap1p activation and its striking requirement for distinct homodimeric subunits give cells the capacity to switch between coordinated and uncoupled RP and glycolytic gene regulation." @default.
• W2157717340 created "2016-06-24" @default.
• W2157717340 creator A5026117622 @default.
• W2157717340 creator A5042989518 @default.
• W2157717340 date "2001-05-01" @default.
• W2157717340 modified "2023-09-25" @default.
• W2157717340 title "Rap1p Requires Gcr1p and Gcr2p Homodimers to Activate Ribosomal Protein and Glycolytic Genes, Respectively" @default.
• W2157717340 cites W1555086548 @default.
• W2157717340 cites W1833602258 @default.
• W2157717340 cites W1945952122 @default.
• W2157717340 cites W1971314619 @default.
• W2157717340 cites W2005393972 @default.
• W2157717340 cites W2028110618 @default.
• W2157717340 cites W2041940725 @default.
• W2157717340 cites W2043981588 @default.
• W2157717340 cites W2045412127 @default.
• W2157717340 cites W2052562460 @default.
• W2157717340 cites W2052780353 @default.
• W2157717340 cites W2058256157 @default.
• W2157717340 cites W2087950896 @default.
• W2157717340 cites W2088598615 @default.
• W2157717340 cites W2097330051 @default.
• W2157717340 cites W2111817213 @default.
• W2157717340 cites W2130551706 @default.
• W2157717340 cites W2142065811 @default.
• W2157717340 cites W2150926065 @default.
• W2157717340 cites W2155157043 @default.
• W2157717340 cites W2164464592 @default.
• W2157717340 cites W2165011536 @default.
• W2157717340 cites W2165499430 @default.
• W2157717340 doi "https://doi.org/10.1093/genetics/158.1.133" @default.
• W2157717340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461654" @default.
• W2157717340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11333224" @default.
• W2157717340 hasPublicationYear "2001" @default.
• W2157717340 type Work @default.
• W2157717340 sameAs 2157717340 @default.
• W2157717340 citedByCount "57" @default.
• W2157717340 countsByYear W21577173402012 @default.
• W2157717340 countsByYear W21577173402013 @default.
• W2157717340 countsByYear W21577173402014 @default.
• W2157717340 countsByYear W21577173402015 @default.
• W2157717340 countsByYear W21577173402016 @default.
• W2157717340 countsByYear W21577173402017 @default.
• W2157717340 countsByYear W21577173402018 @default.
• W2157717340 countsByYear W21577173402019 @default.
• W2157717340 countsByYear W21577173402020 @default.
• W2157717340 countsByYear W21577173402021 @default.
• W2157717340 countsByYear W21577173402022 @default.
• W2157717340 countsByYear W21577173402023 @default.
• W2157717340 crossrefType "journal-article" @default.
• W2157717340 hasAuthorship W2157717340A5026117622 @default.
• W2157717340 hasAuthorship W2157717340A5042989518 @default.
• W2157717340 hasBestOaLocation W21577173401 @default.
• W2157717340 hasConcept C104317684 @default.
• W2157717340 hasConcept C138885662 @default.
• W2157717340 hasConcept C143065580 @default.
• W2157717340 hasConcept C165864922 @default.
• W2157717340 hasConcept C179926584 @default.
• W2157717340 hasConcept C181199279 @default.
• W2157717340 hasConcept C188082640 @default.
• W2157717340 hasConcept C20251656 @default.
• W2157717340 hasConcept C38062823 @default.
• W2157717340 hasConcept C41895202 @default.
• W2157717340 hasConcept C54355233 @default.
• W2157717340 hasConcept C55493867 @default.
• W2157717340 hasConcept C67705224 @default.
• W2157717340 hasConcept C86339819 @default.
• W2157717340 hasConcept C86803240 @default.
• W2157717340 hasConcept C88045685 @default.
• W2157717340 hasConcept C88478588 @default.
• W2157717340 hasConcept C95444343 @default.
• W2157717340 hasConceptScore W2157717340C104317684 @default.
• W2157717340 hasConceptScore W2157717340C138885662 @default.
• W2157717340 hasConceptScore W2157717340C143065580 @default.
• W2157717340 hasConceptScore W2157717340C165864922 @default.
• W2157717340 hasConceptScore W2157717340C179926584 @default.
• W2157717340 hasConceptScore W2157717340C181199279 @default.
• W2157717340 hasConceptScore W2157717340C188082640 @default.
• W2157717340 hasConceptScore W2157717340C20251656 @default.
• W2157717340 hasConceptScore W2157717340C38062823 @default.
• W2157717340 hasConceptScore W2157717340C41895202 @default.
• W2157717340 hasConceptScore W2157717340C54355233 @default.
• W2157717340 hasConceptScore W2157717340C55493867 @default.
• W2157717340 hasConceptScore W2157717340C67705224 @default.
• W2157717340 hasConceptScore W2157717340C86339819 @default.
• W2157717340 hasConceptScore W2157717340C86803240 @default.
• W2157717340 hasConceptScore W2157717340C88045685 @default.
• W2157717340 hasConceptScore W2157717340C88478588 @default.
• W2157717340 hasConceptScore W2157717340C95444343 @default.
• W2157717340 hasIssue "1" @default.
• W2157717340 hasLocation W21577173401 @default.
• W2157717340 hasLocation W21577173402 @default.
• W2157717340 hasOpenAccess W2157717340 @default.
• W2157717340 hasPrimaryLocation W21577173401 @default.
• W2157717340 hasRelatedWork W1507023994 @default.
• W2157717340 hasRelatedWork W1519902998 @default.
• W2157717340 hasRelatedWork W1760488055 @default.
• W2157717340 hasRelatedWork W2086282504 @default.

• next