FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157723767> ?p ?o ?g. }

• W2157723767 endingPage "537" @default.
• W2157723767 startingPage "524" @default.
• W2157723767 abstract "Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lowering fetal androgen and Insl3 hormone levels. Simvastatin (SMV) is a cholesterol-lowering drug that directly inhibits HMG-CoA reductase. SMV may also disrupt steroid biosynthesis, but through a different mode of action (MOA) than the PEs. As cholesterol is a precursor of steroid hormone biosynthesis, we hypothesized that in utero exposure to SMV during the critical period of sex differentiation would lower fetal testicular testosterone (T) production without affecting genes involved in cholesterol and androgen synthesis and transport. Secondly, we hypothesized that a mixture of SMV and a PE, which may have different MOAs, would reduce testosterone levels in an additive manner. Pregnant Sprague Dawley rats were dosed orally with SMV, dipentyl phthalate (DPeP), or SMV plus DPeP from gestational days 14-18, and fetuses were evaluated on GD18. On GD18, SMV lowered fetal T production and serum triglycerides, low density lipoprotein, high density lipoprotein, and total cholesterol levels, and downregulated two genes in the fetal testis that were different from those altered by PEs. When SMV and DPeP were administered as a mixture, fetal T production was significantly reduced in an additive manner, thus demonstrating that a mixture of chemicals can induce additive effects on fetal T production even though they display different MOAs." @default.
• W2157723767 created "2016-06-24" @default.
• W2157723767 creator A5011535800 @default.
• W2157723767 creator A5016081711 @default.
• W2157723767 creator A5033269290 @default.
• W2157723767 creator A5053170273 @default.
• W2157723767 creator A5070194980 @default.
• W2157723767 creator A5071490929 @default.
• W2157723767 creator A5071684798 @default.
• W2157723767 creator A5075983269 @default.
• W2157723767 creator A5090161893 @default.
• W2157723767 date "2014-10-01" @default.
• W2157723767 modified "2023-10-16" @default.
• W2157723767 title "Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat" @default.
• W2157723767 cites W1534699237 @default.
• W2157723767 cites W1974079370 @default.
• W2157723767 cites W1974321365 @default.
• W2157723767 cites W1992733538 @default.
• W2157723767 cites W2003163696 @default.
• W2157723767 cites W2014287839 @default.
• W2157723767 cites W2021591445 @default.
• W2157723767 cites W2031890829 @default.
• W2157723767 cites W2043233190 @default.
• W2157723767 cites W2044132381 @default.
• W2157723767 cites W2046487222 @default.
• W2157723767 cites W2046494933 @default.
• W2157723767 cites W2047658748 @default.
• W2157723767 cites W2060949500 @default.
• W2157723767 cites W2062575149 @default.
• W2157723767 cites W2078846694 @default.
• W2157723767 cites W2080035881 @default.
• W2157723767 cites W2081295656 @default.
• W2157723767 cites W2082009408 @default.
• W2157723767 cites W2083690559 @default.
• W2157723767 cites W2096787550 @default.
• W2157723767 cites W2097972057 @default.
• W2157723767 cites W2104239694 @default.
• W2157723767 cites W2108363745 @default.
• W2157723767 cites W2111854468 @default.
• W2157723767 cites W2117035262 @default.
• W2157723767 cites W2120258670 @default.
• W2157723767 cites W2125149319 @default.
• W2157723767 cites W2130235559 @default.
• W2157723767 cites W2135798900 @default.
• W2157723767 cites W2137516638 @default.
• W2157723767 cites W2145780321 @default.
• W2157723767 cites W2148029218 @default.
• W2157723767 cites W2157936339 @default.
• W2157723767 cites W2164482170 @default.
• W2157723767 cites W2321631825 @default.
• W2157723767 cites W2330284764 @default.
• W2157723767 cites W4239417583 @default.
• W2157723767 doi "https://doi.org/10.1093/toxsci/kfu149" @default.
• W2157723767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4200049" @default.
• W2157723767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25055962" @default.
• W2157723767 hasPublicationYear "2014" @default.
• W2157723767 type Work @default.
• W2157723767 sameAs 2157723767 @default.
• W2157723767 citedByCount "33" @default.
• W2157723767 countsByYear W21577237672015 @default.
• W2157723767 countsByYear W21577237672016 @default.
• W2157723767 countsByYear W21577237672017 @default.
• W2157723767 countsByYear W21577237672018 @default.
• W2157723767 countsByYear W21577237672019 @default.
• W2157723767 countsByYear W21577237672020 @default.
• W2157723767 countsByYear W21577237672021 @default.
• W2157723767 countsByYear W21577237672022 @default.
• W2157723767 countsByYear W21577237672023 @default.
• W2157723767 crossrefType "journal-article" @default.
• W2157723767 hasAuthorship W2157723767A5011535800 @default.
• W2157723767 hasAuthorship W2157723767A5016081711 @default.
• W2157723767 hasAuthorship W2157723767A5033269290 @default.
• W2157723767 hasAuthorship W2157723767A5053170273 @default.
• W2157723767 hasAuthorship W2157723767A5070194980 @default.
• W2157723767 hasAuthorship W2157723767A5071490929 @default.
• W2157723767 hasAuthorship W2157723767A5071684798 @default.
• W2157723767 hasAuthorship W2157723767A5075983269 @default.
• W2157723767 hasAuthorship W2157723767A5090161893 @default.
• W2157723767 hasBestOaLocation W21577237672 @default.
• W2157723767 hasConcept C126322002 @default.
• W2157723767 hasConcept C134018914 @default.
• W2157723767 hasConcept C172680121 @default.
• W2157723767 hasConcept C178790620 @default.
• W2157723767 hasConcept C185592680 @default.
• W2157723767 hasConcept C201614185 @default.
• W2157723767 hasConcept C2777736315 @default.
• W2157723767 hasConcept C2777911890 @default.
• W2157723767 hasConcept C2778163477 @default.
• W2157723767 hasConcept C2778575703 @default.
• W2157723767 hasConcept C2779234561 @default.
• W2157723767 hasConcept C2779279991 @default.
• W2157723767 hasConcept C2781005124 @default.
• W2157723767 hasConcept C54355233 @default.
• W2157723767 hasConcept C71315377 @default.
• W2157723767 hasConcept C71924100 @default.
• W2157723767 hasConcept C86803240 @default.
• W2157723767 hasConceptScore W2157723767C126322002 @default.
• W2157723767 hasConceptScore W2157723767C134018914 @default.

• next