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• W2157729900 abstract "TRPM7 is an essential and ubiquitous channel-kinase regulating cellular influx of Mg2+. Although TRPM7 mRNA is highly abundant, very small amount of the protein is detected in cells, suggesting post-transcriptional regulation of trpm7 gene expression. We found that TRPM7 mRNA 5′-leader contains two evolutionarily conserved upstream open reading frames that act together to drastically inhibit translation of the TRPM7 reading frame at high magnesium levels and ensure its optimal translation at low magnesium levels, when the activity of the channel-kinase is most required. The study provides the first example of magnesium channel synthesis being controlled by Mg2+ in higher eukaryotes." @default.
• W2157729900 created "2016-06-24" @default.
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• W2157729900 date "2014-10-17" @default.
• W2157729900 modified "2023-09-29" @default.
• W2157729900 title "Identification of a Mg2+-sensitive ORF in the 5′-leader of TRPM7 magnesium channel mRNA" @default.
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• W2157729900 doi "https://doi.org/10.1093/nar/gku951" @default.
• W2157729900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4227784" @default.
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