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• W2157730261 abstract "Internalisation of the plant toxin ricin occurs by retrograde transport which delivers the toxin to the ER where it intersects with the MHC class I system for peptide antigen display. Here, we describe the generation of an inactivated, non-toxic, ricin molecule fused to a peptide which elicits a CD8+ T-cell response in mice directed against pneumonia virus of mice, a pneumovirus related to human respiratory syncytial virus. The ricin fusion elicited a significant T-cell response when delivered by intraperitoneal inoculation in the absence of adjuvent. Challenge experiments showed that the T-cell response resulting from inoculation with the ricin-peptide fusion molecule delayed the onset of virus-induced disease." @default.
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• W2157730261 date "2007-02-01" @default.
• W2157730261 modified "2023-09-27" @default.
• W2157730261 title "Stimulation of pneumovirus-specific CD8+ T-cells using a non-toxic recombinant ricin delivery system" @default.
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• W2157730261 doi "https://doi.org/10.1016/j.molimm.2006.03.008" @default.
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