FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157748617> ?p ?o ?g. }

• W2157748617 endingPage "e12322" @default.
• W2157748617 startingPage "e12322" @default.
• W2157748617 abstract "Modulatory descending neurons (DNs) that link the brain to body motor circuits, including dopaminergic DNs (DA-DNs), are thought to contribute to the flexible control of behavior. Dopamine elicits locomotor-like outputs and influences neuronal excitability in isolated body motor circuits over tens of seconds to minutes, but it remains unknown how and over what time scale DA-DN activity relates to movement in behaving animals. To address this question, we identified DA-DNs in the Drosophila brain and developed an electrophysiological preparation to record and manipulate the activity of these cells during behavior. We find that DA-DN spike rates are rapidly modulated during a subset of leg movements and scale with the total speed of ongoing leg movements, whether occurring spontaneously or in response to stimuli. However, activating DA-DNs does not elicit leg movements in intact flies, nor do acute bidirectional manipulations of DA-DN activity affect the probability or speed of leg movements over a time scale of seconds to minutes. Our findings indicate that in the context of intact descending control, changes in DA-DN activity are not sufficient to influence ongoing leg movements and open the door to studies investigating how these cells interact with other descending and local neuromodulatory inputs to influence body motor output." @default.
• W2157748617 created "2016-06-24" @default.
• W2157748617 creator A5014939653 @default.
• W2157748617 creator A5022064026 @default.
• W2157748617 date "2015-03-01" @default.
• W2157748617 modified "2023-09-30" @default.
• W2157748617 title "Activity in descending dopaminergic neurons represents but is not required for leg movements in the fruit fly<i>Drosophila</i>" @default.
• W2157748617 cites W1586109897 @default.
• W2157748617 cites W1588811476 @default.
• W2157748617 cites W1599832486 @default.
• W2157748617 cites W1608846710 @default.
• W2157748617 cites W1805293170 @default.
• W2157748617 cites W1828538530 @default.
• W2157748617 cites W1953114089 @default.
• W2157748617 cites W1966282260 @default.
• W2157748617 cites W1967869064 @default.
• W2157748617 cites W1968358311 @default.
• W2157748617 cites W1968530473 @default.
• W2157748617 cites W1972785770 @default.
• W2157748617 cites W1974387854 @default.
• W2157748617 cites W1977146259 @default.
• W2157748617 cites W1986574990 @default.
• W2157748617 cites W1989717953 @default.
• W2157748617 cites W1995542880 @default.
• W2157748617 cites W1995810888 @default.
• W2157748617 cites W2004366047 @default.
• W2157748617 cites W2006650371 @default.
• W2157748617 cites W2014793858 @default.
• W2157748617 cites W2026255590 @default.
• W2157748617 cites W2033949300 @default.
• W2157748617 cites W2036137808 @default.
• W2157748617 cites W2038370141 @default.
• W2157748617 cites W2038820791 @default.
• W2157748617 cites W2039829972 @default.
• W2157748617 cites W2046738136 @default.
• W2157748617 cites W2053253879 @default.
• W2157748617 cites W2054914622 @default.
• W2157748617 cites W2056883482 @default.
• W2157748617 cites W2060014417 @default.
• W2157748617 cites W2061505696 @default.
• W2157748617 cites W2061945472 @default.
• W2157748617 cites W2068037796 @default.
• W2157748617 cites W2070925479 @default.
• W2157748617 cites W2072920560 @default.
• W2157748617 cites W2073662027 @default.
• W2157748617 cites W2076457657 @default.
• W2157748617 cites W2076834018 @default.
• W2157748617 cites W2081873733 @default.
• W2157748617 cites W2086653658 @default.
• W2157748617 cites W2087804776 @default.
• W2157748617 cites W2088599563 @default.
• W2157748617 cites W2092350392 @default.
• W2157748617 cites W2094968469 @default.
• W2157748617 cites W2096193724 @default.
• W2157748617 cites W2101739564 @default.
• W2157748617 cites W2102791000 @default.
• W2157748617 cites W2117012243 @default.
• W2157748617 cites W2121371476 @default.
• W2157748617 cites W2135972546 @default.
• W2157748617 cites W2144438237 @default.
• W2157748617 cites W2149365532 @default.
• W2157748617 cites W2155540878 @default.
• W2157748617 cites W2156627613 @default.
• W2157748617 cites W2160648569 @default.
• W2157748617 cites W2161887055 @default.
• W2157748617 cites W2166015447 @default.
• W2157748617 cites W2167098513 @default.
• W2157748617 cites W2172683042 @default.
• W2157748617 cites W2245089559 @default.
• W2157748617 cites W2410632883 @default.
• W2157748617 cites W2418359239 @default.
• W2157748617 cites W38478502 @default.
• W2157748617 doi "https://doi.org/10.14814/phy2.12322" @default.
• W2157748617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393157" @default.
• W2157748617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25742959" @default.
• W2157748617 hasPublicationYear "2015" @default.
• W2157748617 type Work @default.
• W2157748617 sameAs 2157748617 @default.
• W2157748617 citedByCount "11" @default.
• W2157748617 countsByYear W21577486172016 @default.
• W2157748617 countsByYear W21577486172017 @default.
• W2157748617 countsByYear W21577486172019 @default.
• W2157748617 countsByYear W21577486172020 @default.
• W2157748617 countsByYear W21577486172023 @default.
• W2157748617 crossrefType "journal-article" @default.
• W2157748617 hasAuthorship W2157748617A5014939653 @default.
• W2157748617 hasAuthorship W2157748617A5022064026 @default.
• W2157748617 hasBestOaLocation W21577486171 @default.
• W2157748617 hasConcept C137183658 @default.
• W2157748617 hasConcept C151730666 @default.
• W2157748617 hasConcept C169760540 @default.
• W2157748617 hasConcept C185263204 @default.
• W2157748617 hasConcept C2779343474 @default.
• W2157748617 hasConcept C2993436365 @default.
• W2157748617 hasConcept C513476851 @default.
• W2157748617 hasConcept C74254510 @default.
• W2157748617 hasConcept C86803240 @default.
• W2157748617 hasConcept C98274493 @default.

• next