FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157763027> ?p ?o ?g. }

• W2157763027 endingPage "492" @default.
• W2157763027 startingPage "485" @default.
• W2157763027 abstract "T3/4.A is a non-mitogenic murine IgA mAb to human CD3 that was selected for clinical studies to provide an alternative for the mitogenic, T cell-activating, therapeutic mAb OKT3. Previously, we reported that T3/4.A is better tolerated in humans than the IgG2a-CD3 mAb T3/4.2a. Here we report the results of a phase II clinical trial to assess the immunosuppressive potential of T3/4.A. Eighteen first kidney transplant recipients with a first rejection episode were included. Baseline immunosuppression consisted of cyclosporin and prednisolone. Rejection treatment consisted of 5 mg mAb per day during 10 days. Fourteen patients responded, of whom four experienced a second rejection within 2 weeks, one experienced chronic rejection after 2.5 years, whereas the others remained rejection-free after treatment (median duration of follow-up 42 months). Four patients did not respond and eventually lost their graft. These results are similar to treatment results with OKT3, as reported in the literature. Following the first dose of T3/4.A, side effects were limited, and reduced compared to OKT3-treated controls. On the second day, 15 patients developed transient vomiting and/or diarrhoea, which coincided with elevated serum levels of proinflammatory cytokines. Minimal or even no side effects occurred during the remaining days, which is in sharp contrast to that seen generally during OKT3 treatment. Both T cell numbers and TCR expression were reduced during the therapy. We conclude that T3/4.A is a good alternative for OKT3 to treat rejection episodes in renal transplant recipients." @default.
• W2157763027 created "2016-06-24" @default.
• W2157763027 creator A5012471784 @default.
• W2157763027 creator A5036345568 @default.
• W2157763027 creator A5047004882 @default.
• W2157763027 creator A5049740893 @default.
• W2157763027 creator A5063666631 @default.
• W2157763027 creator A5082336686 @default.
• W2157763027 creator A5090883710 @default.
• W2157763027 date "2003-08-19" @default.
• W2157763027 modified "2023-10-18" @default.
• W2157763027 title "Treatment of acute kidney allograft rejection with a non-mitogenic CD3 antibody" @default.
• W2157763027 cites W1597952938 @default.
• W2157763027 cites W1602799572 @default.
• W2157763027 cites W1968804518 @default.
• W2157763027 cites W1989483459 @default.
• W2157763027 cites W2004469794 @default.
• W2157763027 cites W2013628010 @default.
• W2157763027 cites W2017714449 @default.
• W2157763027 cites W2030655587 @default.
• W2157763027 cites W2034795374 @default.
• W2157763027 cites W2038539216 @default.
• W2157763027 cites W2042626190 @default.
• W2157763027 cites W2056088597 @default.
• W2157763027 cites W2057043713 @default.
• W2157763027 cites W2060654838 @default.
• W2157763027 cites W2073790391 @default.
• W2157763027 cites W2074463323 @default.
• W2157763027 cites W2079336836 @default.
• W2157763027 cites W2087547757 @default.
• W2157763027 cites W2114355195 @default.
• W2157763027 cites W2117616010 @default.
• W2157763027 cites W2126302947 @default.
• W2157763027 cites W2132837430 @default.
• W2157763027 cites W2136255098 @default.
• W2157763027 cites W2139828067 @default.
• W2157763027 cites W2154207356 @default.
• W2157763027 cites W2157878389 @default.
• W2157763027 cites W2164196729 @default.
• W2157763027 cites W2166421638 @default.
• W2157763027 cites W2167396767 @default.
• W2157763027 cites W2170510141 @default.
• W2157763027 cites W2405839966 @default.
• W2157763027 cites W2413911213 @default.
• W2157763027 cites W4233298376 @default.
• W2157763027 doi "https://doi.org/10.1046/j.1365-2249.2003.02200.x" @default.
• W2157763027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1808785" @default.
• W2157763027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12930378" @default.
• W2157763027 hasPublicationYear "2003" @default.
• W2157763027 type Work @default.
• W2157763027 sameAs 2157763027 @default.
• W2157763027 citedByCount "10" @default.
• W2157763027 countsByYear W21577630272015 @default.
• W2157763027 countsByYear W21577630272020 @default.
• W2157763027 crossrefType "journal-article" @default.
• W2157763027 hasAuthorship W2157763027A5012471784 @default.
• W2157763027 hasAuthorship W2157763027A5036345568 @default.
• W2157763027 hasAuthorship W2157763027A5047004882 @default.
• W2157763027 hasAuthorship W2157763027A5049740893 @default.
• W2157763027 hasAuthorship W2157763027A5063666631 @default.
• W2157763027 hasAuthorship W2157763027A5082336686 @default.
• W2157763027 hasAuthorship W2157763027A5090883710 @default.
• W2157763027 hasBestOaLocation W21577630271 @default.
• W2157763027 hasConcept C114684123 @default.
• W2157763027 hasConcept C126322002 @default.
• W2157763027 hasConcept C159654299 @default.
• W2157763027 hasConcept C167672396 @default.
• W2157763027 hasConcept C203014093 @default.
• W2157763027 hasConcept C2776090121 @default.
• W2157763027 hasConcept C2776715498 @default.
• W2157763027 hasConcept C2780091579 @default.
• W2157763027 hasConcept C2780179540 @default.
• W2157763027 hasConcept C2780252810 @default.
• W2157763027 hasConcept C2780303639 @default.
• W2157763027 hasConcept C2909675724 @default.
• W2157763027 hasConcept C2911091166 @default.
• W2157763027 hasConcept C542903549 @default.
• W2157763027 hasConcept C71924100 @default.
• W2157763027 hasConcept C8891405 @default.
• W2157763027 hasConcept C90924648 @default.
• W2157763027 hasConceptScore W2157763027C114684123 @default.
• W2157763027 hasConceptScore W2157763027C126322002 @default.
• W2157763027 hasConceptScore W2157763027C159654299 @default.
• W2157763027 hasConceptScore W2157763027C167672396 @default.
• W2157763027 hasConceptScore W2157763027C203014093 @default.
• W2157763027 hasConceptScore W2157763027C2776090121 @default.
• W2157763027 hasConceptScore W2157763027C2776715498 @default.
• W2157763027 hasConceptScore W2157763027C2780091579 @default.
• W2157763027 hasConceptScore W2157763027C2780179540 @default.
• W2157763027 hasConceptScore W2157763027C2780252810 @default.
• W2157763027 hasConceptScore W2157763027C2780303639 @default.
• W2157763027 hasConceptScore W2157763027C2909675724 @default.
• W2157763027 hasConceptScore W2157763027C2911091166 @default.
• W2157763027 hasConceptScore W2157763027C542903549 @default.
• W2157763027 hasConceptScore W2157763027C71924100 @default.
• W2157763027 hasConceptScore W2157763027C8891405 @default.
• W2157763027 hasConceptScore W2157763027C90924648 @default.
• W2157763027 hasIssue "3" @default.

• next