FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157764447> ?p ?o ?g. }

• W2157764447 endingPage "11264" @default.
• W2157764447 startingPage "11260" @default.
• W2157764447 abstract "Genetic heterozygosity is thought to enhance resistance of hosts to infectious diseases, but few tests of this idea exist. In particular, heterozygosity at the MHC, the highly polymorphic loci that control immunological recognition of pathogens, is suspected to confer a selective advantage by enhancing resistance to infectious diseases (the heterozygote advantage hypothesis). To test this hypothesis, we released mice into large population enclosures and challenged them with multiple strains of Salmonella and one of Listeria. We found that during Salmonella infections with three avirulent strains, MHC heterozygotes had greater survival and weight than homozygotes (unlike sham controls), and they were more likely to clear chronic Salmonella infection than homozygotes. In laboratory experiments, we found that MHC heterozygosity enhanced the clearance of multiple-strain Salmonella infections. Yet, contrary to what is widely assumed, the benefits of heterozygosity were due to resistance being dominant rather than overdominant, i.e., heterozygotes were more resistant than the average of parental homozygotes, but they were not more resistant than both. The fact that MHC heterozygotes were more resistant to infection and had higher fitness than homozygotes provides a functional explanation for MHC-disassortative mating preferences." @default.
• W2157764447 created "2016-06-24" @default.
• W2157764447 creator A5010067352 @default.
• W2157764447 creator A5028373398 @default.
• W2157764447 creator A5035220521 @default.
• W2157764447 date "2002-08-12" @default.
• W2157764447 modified "2023-10-11" @default.
• W2157764447 title "MHC heterozygosity confers a selective advantage against multiple-strain infections" @default.
• W2157764447 cites W1485104267 @default.
• W2157764447 cites W1508296236 @default.
• W2157764447 cites W1606387712 @default.
• W2157764447 cites W1670761754 @default.
• W2157764447 cites W1672084993 @default.
• W2157764447 cites W1758442221 @default.
• W2157764447 cites W1805678409 @default.
• W2157764447 cites W1817988162 @default.
• W2157764447 cites W1929921649 @default.
• W2157764447 cites W1935228498 @default.
• W2157764447 cites W1966894462 @default.
• W2157764447 cites W1970068443 @default.
• W2157764447 cites W1971302107 @default.
• W2157764447 cites W1980215277 @default.
• W2157764447 cites W1995453338 @default.
• W2157764447 cites W1997144994 @default.
• W2157764447 cites W2009069634 @default.
• W2157764447 cites W2009098553 @default.
• W2157764447 cites W2009618145 @default.
• W2157764447 cites W2038660154 @default.
• W2157764447 cites W2042048278 @default.
• W2157764447 cites W2043637778 @default.
• W2157764447 cites W2055399969 @default.
• W2157764447 cites W2062985060 @default.
• W2157764447 cites W2068020601 @default.
• W2157764447 cites W2074548817 @default.
• W2157764447 cites W2075817888 @default.
• W2157764447 cites W2078214737 @default.
• W2157764447 cites W2089030326 @default.
• W2157764447 cites W2100827722 @default.
• W2157764447 cites W2105609355 @default.
• W2157764447 cites W2123107716 @default.
• W2157764447 cites W2125250020 @default.
• W2157764447 cites W2125341765 @default.
• W2157764447 cites W2136305342 @default.
• W2157764447 cites W2137448116 @default.
• W2157764447 cites W2139308657 @default.
• W2157764447 cites W2145412351 @default.
• W2157764447 cites W2148301632 @default.
• W2157764447 cites W2153984726 @default.
• W2157764447 cites W2172267693 @default.
• W2157764447 cites W2176191850 @default.
• W2157764447 cites W2179152117 @default.
• W2157764447 cites W2184994519 @default.
• W2157764447 cites W2471960492 @default.
• W2157764447 cites W4229803116 @default.
• W2157764447 cites W4241567528 @default.
• W2157764447 cites W4366065282 @default.
• W2157764447 cites W4367169726 @default.
• W2157764447 doi "https://doi.org/10.1073/pnas.162006499" @default.
• W2157764447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/123244" @default.
• W2157764447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12177415" @default.
• W2157764447 hasPublicationYear "2002" @default.
• W2157764447 type Work @default.
• W2157764447 sameAs 2157764447 @default.
• W2157764447 citedByCount "572" @default.
• W2157764447 countsByYear W21577644472012 @default.
• W2157764447 countsByYear W21577644472013 @default.
• W2157764447 countsByYear W21577644472014 @default.
• W2157764447 countsByYear W21577644472015 @default.
• W2157764447 countsByYear W21577644472016 @default.
• W2157764447 countsByYear W21577644472017 @default.
• W2157764447 countsByYear W21577644472018 @default.
• W2157764447 countsByYear W21577644472019 @default.
• W2157764447 countsByYear W21577644472020 @default.
• W2157764447 countsByYear W21577644472021 @default.
• W2157764447 countsByYear W21577644472022 @default.
• W2157764447 countsByYear W21577644472023 @default.
• W2157764447 crossrefType "journal-article" @default.
• W2157764447 hasAuthorship W2157764447A5010067352 @default.
• W2157764447 hasAuthorship W2157764447A5028373398 @default.
• W2157764447 hasAuthorship W2157764447A5035220521 @default.
• W2157764447 hasBestOaLocation W21577644472 @default.
• W2157764447 hasConcept C104317684 @default.
• W2157764447 hasConcept C137848329 @default.
• W2157764447 hasConcept C143589142 @default.
• W2157764447 hasConcept C144024400 @default.
• W2157764447 hasConcept C149923435 @default.
• W2157764447 hasConcept C153471976 @default.
• W2157764447 hasConcept C180754005 @default.
• W2157764447 hasConcept C207936829 @default.
• W2157764447 hasConcept C2781065037 @default.
• W2157764447 hasConcept C2908647359 @default.
• W2157764447 hasConcept C523546767 @default.
• W2157764447 hasConcept C54355233 @default.
• W2157764447 hasConcept C86803240 @default.
• W2157764447 hasConceptScore W2157764447C104317684 @default.
• W2157764447 hasConceptScore W2157764447C137848329 @default.
• W2157764447 hasConceptScore W2157764447C143589142 @default.
• W2157764447 hasConceptScore W2157764447C144024400 @default.

• next