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• W2157772301 abstract "In animal experiments and in cell culture, chronic morphine treatment has been followed by up-regulation as well as down-regulation of the mu-opioid receptor (OR) number. The present postmortem morphometric study of morphine-related fatalities of drug-addicts (n=13, 20-35 years old, with blood unconjugated morphine levels from 27.1 ng/ml to 458 ng/ml, m.v. 198.5 ng/ml) versus a non-addicted control group (n=13, 10-44 years old) was intended to examine, whether chronic opiate exposure affects the numerical density of mu-OR expressing neurons in the human neocortex (areas 11, 24 and 25 according to Brodmann). For the immunohistochemical procedure, vibratome sections (100 microm) were incubated with a monoclonal antibody against the mu-OR, diluted 1:100, and immunolabelled sites were visualized using an immunoperoxidase protocol. The numerical densities of OR immunoreactive neuronal profiles and Nissl-stained central profiles were assessed morphometrically (camera lucida-drawings). In both groups, the anti-mu-OR-immunoreactivity was mainly localized in pyramidal neurons of layers (L) II/III and V and in multiform neurons of L VI. In the areas 24 and 25, the density of the immunoreactive neuronal profiles did not display a significant difference between the two examined groups. In the area 11, however, the number of immunolabelled neuronal profiles amounted to 2777+/-206 mm(3) in the drug-related fatalities and to 2320+/-124 mm(3) in the control group and thus was significantly increased." @default.
• W2157772301 created "2016-06-24" @default.
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• W2157772301 date "2003-05-01" @default.
• W2157772301 modified "2023-10-18" @default.
• W2157772301 title "Area-specific increased density of μ-opioid receptor immunoreactive neurons in the cerebral cortex of drug-related fatalities" @default.
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• W2157772301 doi "https://doi.org/10.1016/s0379-0738(03)00067-7" @default.
• W2157772301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12787653" @default.
• W2157772301 hasPublicationYear "2003" @default.
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